How EpCAM and TROP2 function in the gastrointestinal tract

EpCAM 和 TROP2 如何在胃肠道中发挥作用

• 批准号: 18K07990
• 负责人: Nakato Gaku
• 金额: $ 2.83万
• 依托单位: Kanagawa Institute of Industrial Sclence and Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2018
• 资助国家: 日本
• 起止时间: 2018-04-01 至 2021-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-18K07990/
• 关键词: TROP2; EpCAM; 腸管上皮細胞; 免疫細胞; 粘膜免疫

项目成果

Amelioration of Congenital Tufting Enteropathy in EpCAM (TROP1)-Deficient Mice via Heterotopic Expression of TROP2 in Intestinal Epithelial Cells

• DOI: 10.3390/cells9081847
• 发表时间: 2020-08-01
• 期刊: CELLS
• 影响因子: 6
• 作者: Nakato, Gaku;Morimura, Sohshi;Udey, Mark C.
• 通讯作者: Udey, Mark C.

Matriptase Cleaves EpCAM and TROP2 in Keratinocytes, Destabilizing Both Proteins and Associated Claudins

• DOI: 10.3390/cells9041027
• 发表时间: 2020-04-01
• 期刊: CELLS
• 影响因子: 6
• 作者: Wu, Chuan-Jin;Lu, Michael;Udey, Mark C.
• 通讯作者: Udey, Mark C.