Signal integration at scaffolding proteins: Identification and functional analysis of A-Kinase-Anchoring Proteins in memory processing

学习和记忆需要不同分子信号通路之间协调一致的相互作用，它们共同在大脑中建立一个综合的计算网络。尽管个体通路是众所周知的，但它们整合的分子机制及其与学习和记忆的相关性尚不清楚。最近，我发现a -激酶锚定蛋白家族（AKAPs）就是这样一个分子整合体，使用了完善的果蝇嗅觉调节模式。在这个应用程序中，我应该把这个新的结果加起来，并将讨论以下主题：(1)哪些akap参与不同动机记忆的处理和巩固？(2)在特定的akap上整合了哪些信号通路，分子机制是什么？(3)在细胞水平上保持信号特异性的机制是什么？通过考虑信号计算与大脑的综合性质，回答这些问题将有助于扩展体内记忆处理的当代模型。

Learning and memory requires a concerted interaction between different molecular signaling pathways, which altogether build up an integrative computational network within the brain. Although the individual pathways are well known, the molecular mechanisms of their integration and its relevance for learning and memory are not. Recently, I could identify the family of A-kinase-anchoring-proteins (AKAPs) as one such molecular integrator by use of the well established Drosophila olfactory conditioning paradigm. In this application I should add up on this new result and will address following topics: (1) Which AKAPs are involved in processing and consolidation of differently motivated memories? (2) Which signaling pathways are integrated at the particular AKAPs and what is the molecular mechanism? (3) What is the mechanism that preserves signaling specificity on a cellular level? Answering these questions will help to extend contemporary models of in vivo memory processing by taking into account the integrative nature of signal computation with the brain.