Application of gold-catalyzed 2-ethynylbenzamide cyclization for the tumor-localized in vivo release of anticancer drugs

金催化2-乙炔基苯甲酰胺环化在体内肿瘤局部释放抗癌药物中的应用

• 批准号: 18K14347
• 负责人: Vong Kenward
• 金额: $ 2.66万
• 依托单位: Institute of Physical and Chemical Research
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2018
• 资助国家: 日本
• 起止时间: 2018-04-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-18K14347/
• 关键词: biocompatibility; artificial metalloenzyme; enzymes; gold catalysis; drug release; gold-catalyzed reaction

项目成果

In Vivo Synthetic Chemistry: Overview and Future Outlook

体内合成化学：概述和未来展望

• 发表时间: 2018
• 作者: Kenward Vong;Katsunori Tanaka
• 通讯作者: Katsunori Tanaka

Unlocking the therapeutic potential of artificial metalloenzymes

• DOI: 10.2183/pjab.96.007
• 发表时间: 2020-03
• 期刊: Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
• 作者: Katsunori Tanaka;Kenward Vong

Gold-catalyzed cyclization of alkyne derivatives and its applications

金催化炔烃衍生物环化反应及其应用

• 发表时间: 2018
• 作者: Kenward Vong;Katsunori Tanaka
• 通讯作者: Katsunori Tanaka

2-Benzoylpyridine Ligand Complexation with Gold Critical for Propargyl Ester-Based Protein Labeling

• DOI: 10.1002/chem.201802058
• 发表时间: 2018-07-25
• 期刊: CHEMISTRY-A EUROPEAN JOURNAL
• 影响因子: 4.3
• 作者: Lin, Yixuan;Vong, Kenward;Tanaka, Katsunori
• 通讯作者: Tanaka, Katsunori

An artificial metalloenzyme biosensor can detect ethylene gas in fruits and Arabidopsis leaves

• DOI: 10.1038/s41467-019-13758-2
• 发表时间: 2019-12-17
• 期刊: NATURE COMMUNICATIONS
• 影响因子: 16.6
• 作者: Vong, Kenward;Eda, Shohei;Tanaka, Katsunori
• 通讯作者: Tanaka, Katsunori