Exploration of Therapeutic Target Pathways Involving DNA Repair Genes in High Grade Serous Ovarian Carcinoma

高级别浆液性卵巢癌涉及DNA修复基因的治疗靶点途径探索

• 批准号: 18K15304
• 负责人: Asada Kayo
• 金额: $ 1.66万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2018
• 资助国家: 日本
• 起止时间: 2018-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-18K15304/
• 关键词: 統合的ゲノム解析; 卵巣高異型度漿液性癌; 相同組換修復関連遺伝子変異; PARP阻害剤; 免疫チェックポイント阻害剤

项目成果

Neoantigen load and HLA-class I expression identify a subgroup of tumors with a T-cell-inflamed phenotype and favorable prognosis in homologous recombination-proficient high-grade serous ovarian carcinoma

新抗原负载和 HLA-I 类表达鉴定出具有 T 细胞炎症表型的肿瘤亚组，并且在同源重组熟练的高级别浆液性卵巢癌中具有良好的预后

• DOI: 10.1136/jitc-2019-000375
• 发表时间: 2020
• 期刊: Journal for ImmunoTherapy of Cancer
• 影响因子: 10.9
• 作者: Matsushita Hirokazu;Hasegawa Kosei;Oda Katsutoshi;Yamamoto Shogo;Asada Kayo;Karasaki Takahiro;Yabuno Akira;Nishijima Akira;Nejo Takahide;Kobayashi Yukari;Sato Sho;Ikeda Yuji;Miyai Manami;Takahashi Yusuke;Yamaguchi Rui;Fujiwara Keiichi;Aburatani Hiroyuki;K
• 通讯作者: K

Automated system for diagnosing endometrial cancer by adopting deep-learning technology in hysteroscopy.

• DOI: 10.1371/journal.pone.0248526
• 发表时间: 2021
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Takahashi Y;Sone K;Noda K;Yoshida K;Toyohara Y;Kato K;Inoue F;Kukita A;Taguchi A;Nishida H;Miyamoto Y;Tanikawa M;Tsuruga T;Iriyama T;Nagasaka K;Matsumoto Y;Hirota Y;Hiraike-Wada O;Oda K;Maruyama M;Osuga Y;Fujii T
• 通讯作者: Fujii T

Usefulness of biopsy by office hysteroscopy for endometrial cancer: A case report

• DOI: 10.3892/mco.2020.2053
• 发表时间: 2020-08-01
• 期刊: MOLECULAR AND CLINICAL ONCOLOGY
• 影响因子: 1.2
• 作者: Sone, Kenbun;Eguchi, Satoko;Fujii, Tomoyuki
• 通讯作者: Fujii, Tomoyuki

The histone methyltransferase WHSC1 is regulated by EZH2 and is important for ovarian clear cell carcinoma cell proliferation

• DOI: 10.1186/s12885-019-5638-9
• 发表时间: 2019-05-15
• 期刊: BMC CANCER
• 影响因子: 3.8
• 作者: Kojima, Machiko;Sone, Kenbun;Fujii, Tomoyuki
• 通讯作者: Fujii, Tomoyuki