Molecular targets of volatile anesthetics isoflurane at the calyx of Held synapse.

Held 突触花萼处挥发性麻醉剂异氟烷的分子靶标。

• 批准号: 18K16467
• 负责人: WANG HAN-YING
• 金额: $ 2.66万
• 依托单位: Okinawa Institute of Science and Technology Graduate University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2018
• 资助国家: 日本
• 起止时间: 2018-04-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-18K16467/
• 关键词: Isoflurane; calyx of Held; capacitance measurement; exo-endocytosis; neurotransmission; Calyx of Held; Cerebral cortex; Presynaptic reocrding; Capacitance; Action potential; exocytic machinery; Ion channels; Fidelity

项目成果

Isoflurane preferentially inhibits high-frequency excitatory neurotransmission via directly inhibiting vesicle fusion mechanism.

异氟烷通过直接抑制囊泡融合机制优先抑制高频兴奋性神经传递。

• 发表时间: 2018
• 作者: Han-Ying Wang;Kohgaku Eguchi;Tomoyuki Takahashi
• 通讯作者: Tomoyuki Takahashi

Frequency-Dependent Block of Excitatory Neurotransmission by Isoflurane via Dual Presynaptic Mechanisms.

异氟烷通过双重突触前机制对兴奋性神经传递进行频率依赖性阻断。

• DOI: 10.1523/jneurosci.2946-19.2020
• 发表时间: 2020
• 期刊: Journal of Neuroscience
• 影响因子: 5.3
• 作者: Wang HY;Eguchi K;Yamashita T;Takahashi T.
• 通讯作者: Takahashi T.