Study on the prevention of diabetic nephropathy due to blood TLR ligand derived from periodontal pathogenic microorganisms

牙周病原微生物血液TLR配体预防糖尿病肾病的研究

• 批准号: 18K17305
• 负责人: Kajiwara Koichiro
• 金额: $ 2.75万
• 依托单位: Fukuoka Dental College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2018
• 资助国家: 日本
• 起止时间: 2018-04-01 至 2021-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-18K17305/
• 关键词: 糖尿病性腎症; lipopolysaccharide; P. gingivalis; toll-like receptor; 白血球接着因子; FGF23; ACE2; 口腔衛生; P.gingivalis; LPS; Diabetic nephropathy; VCAM-1; E-selectin; SGLT2; TLR2/4; エリトラン; 歯周疾患; 糖尿病; TLR阻害剤; Porphyromonas gingivalis; 歯周病; 予防医学; TLR

项目成果

Immunohistochemical study for the expression of leukocyte adhesion molecules, and FGF23 and ACE2 in P. gingivalis LPS-induced diabetic nephropathy.

• DOI: 10.1186/s12882-020-02203-y
• 发表时间: 2021-01-06
• 期刊: BMC nephrology
• 影响因子: 2.3
• 作者: Kajiwara K;Sawa Y;Fujita T;Tamaoki S
• 通讯作者: Tamaoki S

Study for the diabetic nephropathy promoted by Porphyromonas gingivalis lipopolysaccharide and the prevension effect by TLR blocker

牙龈卟啉单胞菌脂多糖促进糖尿病肾病及TLR阻滞剂预防作用的研究

• 发表时间: 2018
• 作者: Kajiwara K;Takara K;Takata S;Tamaoki S;Yoshinaga Y;Sawa Y ;Sakagami R.
• 通讯作者: Sakagami R.