Understanding the mechanisms leading to autoimmune adrenalitis by generating the first experimental animal model (A03)

(1)通过评估自身免疫对肾上腺功能和类固醇生成的影响，详细表征实验性自身免疫性肾上腺炎（EAA）模型，并研究炎症细胞向肾上腺的浸润。(2)了解EAA潜在的自身免疫机制，以优化进一步的模型开发。特别是，我们将确定Th1-和th17介导的细胞反应是否在EAA的产生中占主导地位。（三）研究免疫调节干预在EAA背景下的作用。

(I) Characterise in detail the experimental autoimmune adrenalitis (EAA) model by assessing effects of autoimmunity on adrenal function and steroidogenesis as well as investigate the inflammatory cell infiltrate to the adrenal glands.(II) Understand the underlying auto-immune mechanisms of EAA in order to optimize further model development. In particular, we will determine whether Th1- versus Th17-mediated cell responses dominate in EAA generation.(III) Study the role of immunomodulatory interventions in the context of EAA.