Proteins on nanocarriers: from the stealth effect to active targeting in vivo (B11*)

纳米载体上的蛋白质：从隐形效应到体内主动靶向（B11*）

• 批准号: 379153463
• 金额: --
• 依托单位: Max-Planck-Institut für Polymerforschung
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2017
• 资助国家: 德国
• 起止时间: 2016-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/379153463?language=en
• 关键词: Proteins; nanocarriers; stealth; effect; active

Starting with the observation that some nanocarriers build up a protein corona nearly instantaneous-ly in context with serum proteins, which has serious results for cellular uptake and intra-cellular trafficking, this project aims at three different topics. At first it will study possible corona formation on more carrier systems to determine the generality of this phenomenon. Then the applicants want to look for ways to pre-organize desired proteins in the corona to modify biodistribution. At last it is the aim to bind desired proteins like clusterin and/or antibodies chemically to obtain –in this way- a stealth like behavior.

从观察到一些纳米载体几乎瞬间在血清蛋白质的背景下建立蛋白质电晕开始，这对细胞摄取和细胞内运输有严重的结果，该项目针对三个不同的主题。首先，它将研究在更多的载体系统上可能形成的电晕，以确定这种现象的普遍性。然后，申请者希望寻找在日冕中预先组织所需蛋白质的方法，以改变生物分布。最后，它的目标是通过化学方式结合所需的蛋白质，如聚集素和/或抗体，以获得--通过这种方式--隐形行为。