Crossing restrictive biobarriers with self-assembled lipid nanocarriers

用自组装脂质纳米载体跨越限制性生物屏障

• 批准号: DE230101504
• 负责人: Dr Brendan Dyett
• 金额: $ 30.85万
• 依托单位: RMIT University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE230101504
• 关键词: Crossing; restrictive; biobarriers; self; assembled

This project aims to determine how nanoscale objects which mimic the surface of cells behave in biologically relevant environments. This project expects to generate new knowledge in physical chemistry by complementing innovative surface chemistry design and characterisation with data science approaches. The expected outcome of this project is identification of the mode of interaction of these biomimetic objects with cells, which may then reveal a new pathway for the delivery of pharmaceuticals. This could provide significant future benefits in the treatment of neurological diseases and bacterial infections, by overcoming the barrier that the cell surface presents to the uptake of many medicinal drugs.

该项目旨在确定模仿细胞表面的纳米级物体在生物相关环境中的行为。该项目希望通过用数据科学的方法补充创新的表面化学设计和表征来产生物理化学方面的新知识。该项目的预期结果是鉴定这些仿生物体与细胞的相互作用模式，这可能会揭示一种新的药物输送途径。通过克服细胞表面对许多药物的吸收造成的障碍，这可能在未来的神经疾病和细菌感染的治疗中提供显著的好处。