マイクロＲＮＡ欠損による早期老化のメカニズムの解明

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MicroRNA (miRNA) is a small non-coding RNA which represses its target genes at post-transcriptional level. In previous studies, the host researcher established genetically modified mice of several miRNAs which are involved in exercise-induced skeletal muscle adaptation. Coincidentally, we found that certain modification of miRNAs caused accelerated aging. To clarify the aging factor(s), first we determined the aging phenotypes of the GM mice during the fellowship tenure.The average lifespan of GM mice were significantly shorter than those for males and females for WT. The median survival time was also significantly shorter in GM mice than in WT mice. Frailty index of the GM mice was significantly higher than that of WT mice. Collectively, these results suggested that the aging process is accelerated in the GM mice and it eventually shortened the lifespan of the mice.