Hyperpolarized peptide-coated nanodiamonds for magnetic resonance imaging (C06)

用于磁共振成像的超极化肽涂层纳米金刚石 (C06)

• 批准号: 379828295
• 金额: --
• 依托单位: Institut für Experimentelle Tumorforschung
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2017
• 资助国家: 德国
• 起止时间: 2016-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/379828295?language=en
• 关键词: Hyperpolarized; peptide; coated; nanodiamonds; magnetic

Hyperpolarized 13C magnetic resonance imaging (MRI) is a promising tool to monitor the success of cancer treatment but currently requires extremely low temperatures and hour-long polarisation times. This project will use nitrogen-vacancy (NV) centers in nanodiamonds functionalized e.g. with cancer cell targeting peptides, to achieve a ~10,000-fold increase of the 13C nuclear spin polarisation at room temperature. Attachment of peptides to nanodiamonds might also allow to specifically target and detect cancer cells. Thus, this methodology greatly expands the possibilities for in vivo monitoring of molecular processes and holds great promise for biomedical research as well as cancer diagnostics and staging.

超极化13 C磁共振成像（MRI）是一种很有前途的工具，可以监测癌症治疗的成功，但目前需要极低的温度和长达一小时的极化时间。该项目将使用纳米金刚石中的氮空位（NV）中心，例如用癌细胞靶向肽进行功能化，以实现室温下13C核自旋极化的约10，000倍增加。肽与纳米金刚石的连接也可能允许特异性靶向和检测癌细胞。因此，这种方法大大扩展了体内监测分子过程的可能性，并为生物医学研究以及癌症诊断和分期带来了巨大的希望。