Stereocontrol in the intramolecular addition of chromones to alpha-ketoester and alpha,beta-diketoester: syntheses of preussochromones and diversonolic ester

色酮分子内加成到α-酮酯和α,β-二酮酯中的立体控制：普鲁索色酮和二酮酯的合成

• 批准号: 380321759
• 负责人: Professor Dr. Ulrich Koert
• 金额: --
• 依托单位: Arbeitsgruppe Koert Organic Synthesis
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2017
• 资助国家: 德国
• 起止时间: 2016-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/380321759?language=en
• 关键词: Stereocontrol; intramolecular; addition; chromones; alpha

Goal of the project is to investigate the stereoselective, intramolecular addition of chromones to alpha-ketoester and alpha,beta-diketoester. For the planned cyclizations to 5- and 6-membered rings the focus is on possibilities of substrate control by existing stereo centers and of catalyst control by chiral, chelating Lewis acids. Reference points for the proposed studies are the chromone natural products preussochromone A, D, E, F and the diversonolic ester alpha and beta.

该项目的目标是研究色酮与α-酮酯和α，β-二酮酯的立体选择性分子内加成。对于计划的环化为5-和6-元环，重点是通过现有立体中心控制底物和通过手性螯合刘易斯酸控制催化剂的可能性。拟议研究的参考点是色酮天然产物preussochromone A、D、E、F和diversonolic酯α和β。