Titanium/polymer sheets designed for biomedical application; Feasibility study

IMET、TU Clausthal和IPCMS的研究小组Uni Strasburg十年来一直在合作开发和表征用于汽车应用的金属/聚合物组合夹层板材。几年前，它将其活动扩展到生物医学使用领域，在生物兼容材料的组合方面提出了新的挑战。由于环氧树脂的使用对汽车来说不重要，不适用于生物医学用途，因此有必要为这些金属和聚合物材料的组合开发良好和安全的粘接新方法。该项目的总体目标是设计用于生物医学应用的新型钛(钛)/聚合物(P)/钛杂化薄板，控制它们的界面，它们的机械性能和成形行为。这些可用于颅骨成形术和下颌骨手术的系统的优势将是一种轻量级的多层系统，具有分级的强度条件和相对于钛的改善的热学和声学性能，并且具有可设计为接近骨骼的机械性能。这些系统的开发、工艺开发、性能分析及其成形极限预计将在法国和德国合作伙伴的协作下进行，主要目标是：1)使用新开发的化学工艺设计P/Ti界面，不含目前用作汽车夹芯板(SMS)粘合剂的环氧树脂。2)制备钛/磷/钛或钛/磷复合材料，用于颅骨成形术和下颌骨外科手术，其力学性能接近于骨的特性。目前，通过IPCMS的研究，这种新的接枝方法可以成功地应用于10×10 mm的钛表面。聚合引发剂可以通过膦酸锚接枝到改性的钛(1级)薄板表面。聚甲基丙烯酸甲酯(PMMA)的线性高分子链可以通过控制自由基聚合过程从引发剂生长到大约1微米的厚度。这个短时间项目(9个月)的目的是研究使用这种嫁接方法生产夹层板材(针对A6甚至A5尺寸)的可行性。预计这些成果将用于下一个DFG-ANR方案内的一个新的、加强的和最后的双边项目。以均匀的方式制备无缺陷或强烈(软化？)的金属板表面。在金属涂层上的层的差异，2。找到合适的工艺条件将单层结合成带有A3的夹心板。合适的、可重复的结合。

The research group of IMET, TU Clausthal, and IPCMS, Uni Strasbourg, is working together since a decade of years developing and characterizing sandwich sheet materials of metal/polymer combinations for automotive applications. It extended its activities into the field of biomedical use with new challenges concerning the combination of biocompatible materials some years ago. As the use of epoxy resins, uncritical for the automotive, is not applicable for biomedical use, new ways for a good and safe bonding are necessary to be developed for these combinations of metal and polymer materials. The goal of the general project is the design of new titanium(Ti)/polymer(P)/Ti hybrid sheets to be used for biomedical applications, the control of their interface, their mechanical properties and shaping behavior. The advantages of these systems usable for cranioplasty and mandible surgery will be a lightweight multilayer system with graded strength conditions and improved thermal and acoustic properties with respect to titanium alone, and with mechanical properties that can be designed close to the bones ones. The elaboration of these systems, the process development, the analysis of the properties and their forming limits is foreseen to be performed in synergy between the French and German partners with the main objectives:1) Use a new developed chemical process to design P/Ti interfaces free of epoxy resins currently used as adhesive agents in sandwich sheets (SMs) for automotive applications. 2) Fabricating Ti/P/Ti or Ti/P SMs for cranioplasty and mandible surgery with tailored mechanical properties close to the bones behaviour.Up to now, the new grafting from method, investigated by IPCMS, could successfully be introduced for a Ti surface 10 x 10 mm². A polymerization initiator could be grafted on a modified Ti (Grade 1) sheet surface via a phosphonate anchor. Linear polymer chains of polymethylmethacrylate (PMMA) could be grown from the initiator using a controlled radical polymerization process up to a thickness of approximately one micron. The aim of this short time project (9 months) is to investigate the feasibility of using this grafting from method to produce sandwich sheets (aiming at size A6 or even A5). The results are foreseen to be used for a new, strengthened and final bilateral project within the next DFG-ANR program.The steps foreseen are to1. prepare the metal sheet surface in a homogeneous way without defects or strongly (weakening?) differences in the layer coated on the metal,2. find suitable process conditions for combining the single layers to a sandwich sheet with a3. suitable, reproducible bond.