mTOR and its regulation by microRNAs . Influence on pancreatic cancer and diabetes mellitus

mTOR 及其 microRNA 的调节。

• 批准号: 386944891
• 负责人: Dr. Theodoros Kolokotronis
• 金额: --
• 依托单位: Klinik für Allgemein- und Viszeralchirurgie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2017
• 资助国家: 德国
• 起止时间: 2016-12-31 至 2019-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/386944891?language=en
• 关键词: mTOR; its; regulation; microRNAs; Influence

Aim of the present, prospective, observational study is to investigatethe role of mechanistic target of rapamycin (mTOR) on resectablepancreatic cancer (PDAC) and diabetes mellitus (DM). Primary endpoint is, whether the underlying disease (PDAC) and the type ofsurgical resection (pp-Whipple vs. left pancreatectomy) affect theexpression of mTORC1 and 2. Furthermore, a clinical correlationbetween diabetes and mTOR expression will be investigated, as wellas the prognosis in PDAC patients. Micro- RNAs (miRNA) thatregulate mTOR expresssion, as well as its downstream targets will bealso analyzed with the aim to identify potential prognostic markers forpatients with PDAC subjected to surgery.

本前瞻性观察性研究的目的是探讨雷帕霉素（mTOR）在可切除胰腺癌（PDAC）和糖尿病（DM）中的作用。主要终点是，基础疾病（PDAC）和手术切除类型（pp-Whipple vs.左胰切除术）是否影响mTORC1和2的表达。此外，我们还将研究糖尿病与mTOR表达的临床相关性，以及PDAC患者的预后。调控mTOR表达的微rna （miRNA）及其下游靶点也将被分析，目的是确定手术后PDAC患者的潜在预后标志物。