mTOR and its regulation by microRNAs . Influence on pancreatic cancer and diabetes mellitus

本项前瞻性观察性研究的目的是探讨雷帕霉素靶点（mTOR）在可切除胰腺癌（PDAC）和糖尿病（DM）中的作用。主要终点是基础疾病（PDAC）和手术切除类型（pp-Whipple与左胰腺切除术）是否影响mTORC 1和2的表达。此外，还将研究糖尿病与mTOR表达的临床相关性，以及PDAC患者的预后。调节mTOR表达的微小RNA（miRNA）及其下游靶点也将被分析，目的是识别接受手术的PDAC患者的潜在预后标志物。

Aim of the present, prospective, observational study is to investigatethe role of mechanistic target of rapamycin (mTOR) on resectablepancreatic cancer (PDAC) and diabetes mellitus (DM). Primary endpoint is, whether the underlying disease (PDAC) and the type ofsurgical resection (pp-Whipple vs. left pancreatectomy) affect theexpression of mTORC1 and 2. Furthermore, a clinical correlationbetween diabetes and mTOR expression will be investigated, as wellas the prognosis in PDAC patients. Micro- RNAs (miRNA) thatregulate mTOR expresssion, as well as its downstream targets will bealso analyzed with the aim to identify potential prognostic markers forpatients with PDAC subjected to surgery.