The organization of structural lipids in synaptic membranes (B01)

突触膜中结构脂质的组织（B01）

• 批准号: 386956849
• 金额: --
• 依托单位: Center for Biostructural Imaging of Neurodegeneration (BIN)
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2017
• 资助国家: 德国
• 起止时间: 2016-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/386956849?language=en
• 关键词: organization; structural; lipids; synaptic; membranes

The lipid composition of the synapse has been difficult to study. Structural lipids, including abundant phospholipids, cholesterol or sphingolipids, are poorly understood. Their concentrations in synaptic membranes are unclear, and their distributions are virtually unknown. I propose to approach this problem by combining two state-of-the-art lipid analysis tools, based on secondary ion mass spectrometry (SIMS): time-of-flight SIMS (ToF-SIMS), and nanoscale SIMS (NanoSIMS).

突触的脂质组成一直难以研究。结构脂，包括丰富的磷脂、胆固醇或鞘脂，了解甚少。它们在突触膜中的浓度尚不清楚，它们的分布几乎是未知的。我建议通过结合两种最先进的基于二次离子质谱（SIMS）的脂质分析工具来解决这个问题：飞行时间SIMS （ToF-SIMS）和纳米尺度SIMS （NanoSIMS）。