Photoacids and bases as responsive elements in block copolymer nanostructures for uptake and transport (A03)

光酸和光碱作为嵌段共聚物纳米结构中吸收和运输的响应元件（A03）

• 批准号: 387318883
• 金额: --
• 依托单位: Institut für Organische Chemie und Makromolekulare Chemie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/387318883?language=en
• 关键词: Photoacids; bases; responsive; elements; block

The project addresses triggered drug release by red / NIR light from new polymeric nanocontainers. To this end we research different block copolymer concepts to couple triplet-triplet annihilation upconversion to chemical reactivity of photoacids and photobases leading to drug release. Furthermore, based on polymers developed during the first funding period we will study the light-mediated formation and dissociation of interpolyelectrolyte complexes (IPECs) as another tool for drug transport and temporally controlled release.

该项目利用红光/近红外光从新型聚合物纳米容器中触发药物释放。为此，我们研究了不同的嵌段共聚物概念，将三重态-三重态湮灭上转化与光酸和光碱的化学反应性耦合，从而导致药物释放。此外，基于第一个资助期开发的聚合物，我们将研究光介导的多电解质间复合物（ipec）的形成和解离，作为药物运输和暂时控制释放的另一种工具。