Selective targeting of hepatocytes using multifunctional block copolymer micelles to restore critical cellular signaling functions (C03)

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The aim of this project is to design multifunctional core-shell-corona micelles with controllable size, net charge, and charge density that allow for cell-type specific delivery of siRNA into hepatocytes while deliberately avoiding macrophages. Covalent placement of targeting dyes on the surface of the nanostructures (e.g., polymethine dyes) will be a strategy to achieve an efficient and cell-type specific delivery of phosphoinositid-3-kinase (PI3K)-γ attacking substances reflecting a promising strategy to prevent sepsis-associated hepatic dysfunction.