Selective targeting of hepatocytes using multifunctional block copolymer micelles to restore critical cellular signaling functions (C03)

使用多功能嵌段共聚物胶束选择性靶向肝细胞以恢复关键的细胞信号传导功能 (C03)

• 批准号: 387994598
• 金额: --
• 依托单位: Institut für Organische Chemie und Makromolekulare Chemie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2017
• 资助国家: 德国
• 起止时间: 2016-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/387994598?language=en
• 关键词: Selective; targeting; hepatocytes; using; multifunctional

The aim of this project is to design multifunctional core-shell-corona micelles with controllable size, net charge, and charge density that allow for cell-type specific delivery of siRNA into hepatocytes while deliberately avoiding macrophages. Covalent placement of targeting dyes on the surface of the nanostructures (e.g., polymethine dyes) will be a strategy to achieve an efficient and cell-type specific delivery of phosphoinositid-3-kinase (PI3K)-γ attacking substances reflecting a promising strategy to prevent sepsis-associated hepatic dysfunction.

该项目的目的是设计具有可控尺寸、净电荷和电荷密度的多功能核-壳-冠胶束，其允许siRNA向肝细胞中的细胞类型特异性递送，同时故意避免巨噬细胞。靶向染料在纳米结构表面上的共价放置（例如，聚甲炔染料）将是实现磷酸肌醇-3-激酶（PI 3 K）-γ攻击物质的有效和细胞类型特异性递送的策略，反映了预防脓毒症相关肝功能障碍的有前景的策略。