SusChEM: Chiral Silanediols in Anion-Binding Catalysis

在这个由化学学部化学催化项目资助的项目中，俄亥俄州立大学化学与生物化学系的Anita E. Mattson教授正在研究复杂靶分子可持续构建的催化策略。具体来说，新型硅二醇基催化剂正被用于开发无金属化学工艺。这项工作的广泛影响包括发现合成对环境危害较小的有价值化学品的策略，以及为有抱负的化学家（包括研究生，本科生和高中生）提供培训场地，以获得技能，帮助他们成长为下一代科学研究者。当地的高中学生和教师正在通过马特森教授开发的外展项目了解无害环境的催化剂系统的重要性。这项研究的信息可以为材料、药物和精细化学品的合成提供更可持续的机会。硅二醇是一种新型的无金属催化剂，目前正在研究其作为一种环境友好的工具来构建药物制剂和材料。该方法依赖于合成和表征新的手性硅二醇催化剂家族，探索硅二醇结构对催化活性的影响，探索硅二醇催化过程的机理。人们对多种硅二醇催化剂进行了研究，并建立了它们的结构和功能之间的关系。最有前途的硅二醇正在被研究作为合成生物活性分子的催化剂。

In this project funded by the Chemical Catalysis program of the Chemistry Division, Professor Anita E. Mattson of the Department of Chemistry and Biochemistry at The Ohio State University is investigating catalysis strategies for the sustainable construction of complex target molecules. Specifically, new silanediol-based catalysts are being advanced for development in metal-free chemical processes. The broader impacts of this work include the discovery of strategies to synthesize valuable chemicals with less harm to the environment and the development of a training ground for aspiring chemists, including graduate, undergraduate and high school students, to acquire skills to help them grow into the next generation of scientific investigators. Local high school students and teachers are learning about the importance of environmentally benign catalyst systems through an outreach program developed by Professor Mattson. The information from this study can provide opportunities to make the syntheses of materials, medicines, and fine chemicals more sustainable. Silanediols, a new family of metal-free catalysts, are under investigation as environmentally benign tools for the construction of pharmaceutical agents and materials. The approach relies on synthesizing and characterizing new families of chiral silanediol catalysts, probing how silanediol structure affects catalytic activity, and exploring the mechanism of silanediol-catalyzed processes. A variety of silanediol catalysts are being studied and correlations between their structure and function are being established. The most promising silanediols are under examination as catalysts for the syntheses of bioactive molecules.