SusChEM: Chiral Silanediols in Anion-Binding Catalysis

在这个由化学系化学催化计划资助的项目中，俄亥俄州立大学化学和生物化学系的Anita E.Mattson教授正在研究可持续构建复杂目标分子的催化策略。具体地说，新的硅二醇基催化剂正在为无金属化学工艺的开发而进步。这项工作的更广泛影响包括发现合成对环境危害较小的有价值化学品的策略，以及为有抱负的化学家，包括研究生、本科生和高中生开发培训基地，以获得技能，帮助他们成长为下一代科学研究人员。当地的高中生和教师正在通过马特森教授开发的一个推广项目，学习环保催化剂系统的重要性。这项研究的信息可以提供机会，使材料、药物和精细化学品的合成更可持续。硅烷二醇是一种新的无金属催化剂家族，作为构建药剂和材料的环境友好工具正在进行研究。该方法依赖于合成和表征新型手性硅烷二醇催化剂，探索硅烷二醇结构对催化活性的影响，并探索硅烷二醇催化过程的机理。人们正在研究各种硅烷二醇催化剂，并正在建立它们的结构和功能之间的相关性。目前正在研究最有希望的硅烷二醇作为合成生物活性分子的催化剂。

In this project funded by the Chemical Catalysis program of the Chemistry Division, Professor Anita E. Mattson of the Department of Chemistry and Biochemistry at The Ohio State University is investigating catalysis strategies for the sustainable construction of complex target molecules. Specifically, new silanediol-based catalysts are being advanced for development in metal-free chemical processes. The broader impacts of this work include the discovery of strategies to synthesize valuable chemicals with less harm to the environment and the development of a training ground for aspiring chemists, including graduate, undergraduate and high school students, to acquire skills to help them grow into the next generation of scientific investigators. Local high school students and teachers are learning about the importance of environmentally benign catalyst systems through an outreach program developed by Professor Mattson. The information from this study can provide opportunities to make the syntheses of materials, medicines, and fine chemicals more sustainable. Silanediols, a new family of metal-free catalysts, are under investigation as environmentally benign tools for the construction of pharmaceutical agents and materials. The approach relies on synthesizing and characterizing new families of chiral silanediol catalysts, probing how silanediol structure affects catalytic activity, and exploring the mechanism of silanediol-catalyzed processes. A variety of silanediol catalysts are being studied and correlations between their structure and function are being established. The most promising silanediols are under examination as catalysts for the syntheses of bioactive molecules.