SusChEM: Chiral Silanediols in Anion-Binding Catalysis

在这个由化学系化学催化项目资助的项目中，Anita E.俄亥俄州州立大学化学和生物化学系的Mattson正在研究复杂目标分子可持续构建的催化策略。具体而言，新的基于硅烷二醇的催化剂正在被推进用于无金属化学工艺的开发。 这项工作的更广泛影响包括发现合成对环境危害较小的有价值化学品的策略，以及为有抱负的化学家（包括研究生，本科生和高中生）提供培训基地，以获得技能，帮助他们成长为下一代科学研究人员。当地的高中学生和教师正在通过马特森教授开发的一个推广项目了解环境友好型催化剂系统的重要性。这项研究的信息可以为材料，药物和精细化学品的合成提供更可持续的机会。 硅烷二醇是一种新型的无金属催化剂，正作为环境友好的药物制剂和材料的构建工具进行研究。该方法依赖于合成和表征新的手性硅烷二醇催化剂家族，探索硅烷二醇结构如何影响催化活性，并探索硅烷二醇催化过程的机理。 正在研究各种硅烷二醇催化剂，并建立它们的结构和功能之间的关联。最有前途的硅烷二醇作为催化剂用于生物活性分子的合成正在研究中。

In this project funded by the Chemical Catalysis program of the Chemistry Division, Professor Anita E. Mattson of the Department of Chemistry and Biochemistry at The Ohio State University is investigating catalysis strategies for the sustainable construction of complex target molecules. Specifically, new silanediol-based catalysts are being advanced for development in metal-free chemical processes. The broader impacts of this work include the discovery of strategies to synthesize valuable chemicals with less harm to the environment and the development of a training ground for aspiring chemists, including graduate, undergraduate and high school students, to acquire skills to help them grow into the next generation of scientific investigators. Local high school students and teachers are learning about the importance of environmentally benign catalyst systems through an outreach program developed by Professor Mattson. The information from this study can provide opportunities to make the syntheses of materials, medicines, and fine chemicals more sustainable. Silanediols, a new family of metal-free catalysts, are under investigation as environmentally benign tools for the construction of pharmaceutical agents and materials. The approach relies on synthesizing and characterizing new families of chiral silanediol catalysts, probing how silanediol structure affects catalytic activity, and exploring the mechanism of silanediol-catalyzed processes. A variety of silanediol catalysts are being studied and correlations between their structure and function are being established. The most promising silanediols are under examination as catalysts for the syntheses of bioactive molecules.