The role of host cell proteins in survival and propagation of the human malaria parasite P. falciparum.

宿主细胞蛋白在人类疟原虫恶性疟原虫存活和繁殖中的作用。

• 批准号: 391524768
• 负责人: Professor Dr. Jude Marek Przyborski
• 金额: --
• 依托单位: Professur für Biochemie und Molekularbiologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2017
• 资助国家: 德国
• 起止时间: 2016-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/391524768?language=en
• 关键词: role; host; cell; proteins; survival

The malaria parasite P. falciparum modifies its chosen host cell, the mature human erythrocyte. This modification is mediated by a number of parasite-encoded proteins that are transported to the host cell. It is however not clear how these proteins are transported to the host cell. This project aims to understand this process. Our hypothesis is that human proteins are recruited by the parasite to aid in transport of its own proteins to the host erythrocyte. Using a variety of methods, we aim to study the role of human chaperones in this process. Potential new mechanisms which we uncover may provide a potential achilles heel for development of anti-parasite therapies.

恶性疟原虫会改变它所选择的宿主细胞，即成熟的人类红细胞。这种修饰是由许多寄生虫编码的蛋白质介导的，这些蛋白质被转运到宿主细胞。然而，尚不清楚这些蛋白质是如何转运到宿主细胞的。本项目旨在了解这一过程。我们的假设是，人类蛋白质被寄生虫招募，以帮助其自身的蛋白质运输到宿主红细胞。使用各种方法，我们的目标是研究人类伴侣在这一过程中的作用。我们发现的潜在的新机制可能为抗寄生虫疗法的发展提供潜在的致命弱点。