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The role of host cell proteins in survival and propagation of the human malaria parasite P. falciparum.

The role of host cell proteins in survival and propagation of the human malaria parasite P. falciparum.
宿主细胞蛋白在人类疟原虫恶性疟原虫存活和繁殖中的作用。
批准号:
391524768
负责人:
Professor Dr. Jude Marek Przyborski
金额:
$0.0万
依托单位国家:
德国
项目类别:
Research Grants
财政年份:
2017
资助国家:
德国
项目状态:
已结题
起止时间:
2016-12-31 至 2020-12-31

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中文摘要
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英文摘要
The malaria parasite P. falciparum modifies its chosen host cell, the mature human erythrocyte. This modification is mediated by a number of parasite-encoded proteins that are transported to the host cell. It is however not clear how these proteins are transported to the host cell. This project aims to understand this process. Our hypothesis is that human proteins are recruited by the parasite to aid in transport of its own proteins to the host erythrocyte. Using a variety of methods, we aim to study the role of human chaperones in this process. Potential new mechanisms which we uncover may provide a potential achilles heel for development of anti-parasite therapies.
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会议论文
Trafficking and sorting of proteins to the parasitophorous vacuolar membrane of the malaria parasite P. falciparum: Exp1 as a model.
Cell biology of apicomplexans
Molecular interactions of chaperones as a target for anti-malarial drug development
  • 批准号:
    271495877
  • 项目类别:
    Research Grants
  • 资助金额:
    $0.0万
  • 财政年份:
    2015
  • 负责人:
    Professor Dr. Jude Marek Przyborski
  • 依托单位:
Exported chaperones/co-chaperones of P. falciparum: Interaction with host proteins, and relevance for intra-erythrocytic survival of the parasite
国内基金
海外基金
lncRNA-HOST2—USP15—VGLL4轴促进乳腺癌肝转移的机制研究
  • 批准号:
    82073204
  • 项目类别:
    面上项目
  • 资助金额:
    55.0万元
  • 批准年份:
    2020
  • 负责人:
    房林
  • 依托单位:
新鉴定PA-X“host-shutoff”功能区调控H7N9禽流感病毒毒力的机制
  • 批准号:
    32072832
  • 项目类别:
    面上项目
  • 资助金额:
    58.0万元
  • 批准年份:
    2020
  • 负责人:
    胡娇
  • 依托单位:
能量代谢触发植入干细胞和损伤视网膜细胞Graft-to Host细胞间通讯/物质交换及命运转变的机制
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