Preparation and characterisation of bioactive anion-modified hydroxyapatite particles: Protein adsorption mechanism on biomaterials

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It is well accepted that ion-substituted HAp particles can be used as carriers of proteins and their controlled release for bone regeneration. Very little is known of the structure of the surface sites (molecular groups) of the inorganic carrier nanoparticles and, most importantly, of the protein binding mechanism to these surfaces. This project aims to investigate (i) the structure, particularly of the surface sites of borate substituted HAp and (ii) the mechanism of the protein release from the such modified HAp particles by combining the expertise of the two research teams at the BAM and in Okayama. The Japanese site focuses on the preparation of the materials and the protein adsorption measurements whereas the Berlin term is responsible for all structural characterisations, preferably using solid state NMR, including first efforts to explore the possibilities for monitoring the protein adsorption/binding using unlabelled samples.