Central project B: Service Unit for lung specimen (clinical and experimental, former part of project 3)

中心项目B：肺标本服务单位（临床和实验，项目3的前部分）

• 批准号: 39175165
• 负责人: Professor Dr. Tobias Welte (†)
• 金额: --
• 依托单位: Klinik für Pneumologie und Infektiologie
• 依托单位国家: 德国
• 项目类别: Clinical Research Units
• 财政年份: 2007
• 资助国家: 德国
• 起止时间: 2006-12-31 至 2010-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/39175165?language=en
• 关键词: Central; project; Service; Unit; lung

The extent of the lung transplantation (LTx) program at Hannover Medical School allows the development of a worldwide unique data and material base of human and animal tissues that can be extremely useful for a multitude of scientific and clinical questions. During the first funding period, BAL, pulmonary brush aspirates and blood samples were already collected from LTx patients for use in project 3. With regard to the growing demand for collection of such materials including lung biopsies from lung transplanted patients and large animal recipients, a Central Service Unit for obtaining, processing, storage, and documentation of such materials will be established. The resulting data base of the Central Service Unit will be integrated into the already existing clinical data base. In general, all procedures, which have been previously applied in project 3, like bronchial-alveolar lavage, bronchial brushing, as well as collection of lung tissue samples will be accessible for the clinical, as well as for the experimental projects. In addition, a surveillance biopsy program will be established in all patients in the first 12 months after lung transplantation. In preliminary studies with indication bronchoscopies, we could demonstrate that a biopsy program is feasible, safe, and important for clinical decisions. The specimen obtained in the surveillance biopsy program are essential for the projects no. 3 and 9, but will be available for all other projects with requirement of human biopsy material. The establishment of this Central Service Unit will be of major importance for sustainability for the clinical research group during and beyond the granted period.

汉诺威医学院的肺移植(LTX)计划的范围允许开发全球独特的人类和动物组织数据和材料基础，这对解决大量科学和临床问题非常有用。在第一个资助期内，已经从LTX患者身上收集了肺泡灌洗液、肺刷吸液和血液样本，供项目3使用。对于收集此类材料的需求日益增长，包括肺移植患者和大型动物接受者的肺活检，将设立一个中央服务股，负责获取、处理、存储和记录此类材料。由此产生的中央服务股数据库将并入现有的临床数据库。一般而言，项目3以前应用的所有程序，如支气管肺泡灌洗、支气管刷洗以及肺组织样本采集，都将可供临床和实验项目使用。此外，在肺移植后的头12个月内，将在所有患者中建立监测活检计划。在适应症支气管镜检查的初步研究中，我们可以证明活检方案是可行的、安全的，并且对临床决策很重要。在监测活组织检查计划中获得的标本对3号和9号项目是必不可少的，但将可用于所有其他需要人类活组织检查材料的项目。这一中央服务股的建立对临床研究小组在授权期内和之后的可持续性具有重要意义。