Analysis of protein nano-environments of the voltage-gated P/Q-type Ca2+ channels Cav2.1 in the CN (P16)

电压门控Ca2+ (Cav)通道通过在Cav通道周围的纳米环境中发生的局部Ca2+信号，将兴奋性与多种细胞过程联系起来。在结构上，这些纳米环境是扩展的蛋白质网络，由Cav通道与不同的伙伴蛋白质共同组装和随后各个模块之间的交叉相互作用产生。本项目分析了cav2.1相关蛋白网络的形成和结构，并研究了网络排列和单个模块对中枢神经元中cav2.1驱动的局部Ca2+信号传导的意义。

Voltage-gated Ca2+ (Cav) channels link excitability to a large variety of cellular processes via local Ca2+ signalling occuring in the nano-environment(s) around Cav channels. Structurally, these nano-environments are extended protein networks resulting from co-assembly of Cav channels with distinct partner proteins and subsequent cross-interactions between individual modules. This project analyzes formation and architecture of Cav2.1-associated protein networks and investigates the significance of the network arrangement and of individual modules for the Cav-driven local Ca2+-signalling in central neurons.