Analysis of protein nano-environments of the voltage-gated P/Q-type Ca2+ channels Cav2.1 in the CN (P16)

CN 中电压门控 P/Q 型 Ca2 通道 Cav2.1 的蛋白质纳米环境分析 (P16)

• 批准号: 39256213
• 金额: --
• 依托单位: Lehrstuhl für Physiologie II - Molecular Physiology
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2007
• 资助国家: 德国
• 起止时间: 2006-12-31 至 2017-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/39256213?language=en
• 关键词: Analysis; protein; nano; environments; voltage

Voltage-gated Ca2+ (Cav) channels link excitability to a large variety of cellular processes via local Ca2+ signalling occuring in the nano-environment(s) around Cav channels. Structurally, these nano-environments are extended protein networks resulting from co-assembly of Cav channels with distinct partner proteins and subsequent cross-interactions between individual modules. This project analyzes formation and architecture of Cav2.1-associated protein networks and investigates the significance of the network arrangement and of individual modules for the Cav-driven local Ca2+-signalling in central neurons.

电压门控Ca 2+（Cav）通道通过Cav通道周围纳米环境中发生的局部Ca 2+信号传导将兴奋性与多种细胞过程联系起来。在结构上，这些纳米环境是由Cav通道与不同的伙伴蛋白的共组装以及随后的各个模块之间的交叉相互作用而产生的扩展的蛋白质网络。该项目分析了Cav2.1相关蛋白网络的形成和结构，并研究了网络排列和单个模块对中央神经元中Cav-driven局部Ca 2+信号传导的意义。