Dynamic single-cell analysis instrument to evaluate immune cell function

动态单细胞分析仪评估免疫细胞功能

基本信息

  • 批准号:
    10699036
  • 负责人:
  • 金额:
    $ 32.43万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-05-01 至 2024-07-31
  • 项目状态:
    已结题

项目摘要

7. Project Summary/Abstract Recent decades have been marked by a revolution in single-cell analytical techniques, instruments and software tools that have markedly improved our understanding of biology. A high-profile example has been the emergence of single-cell sequencing to move from bulk genomic and transcriptomic analysis to single-cell resolution that reveals the heterogeneity of individual cells. Similar trends have been observed in protein analysis, spatial transcriptomics, and other disciplines. However, there remains a critical unmet need in understanding individual cellular function, movement, interactions, and other measures of performance. The genesis of cells as living drugs requires the development of technologies that can characterize the function and performance of massive numbers of cells at single-cell resolution to support development of new therapies and clinical biomarkers. Unfortunately, existing technologies are either not scalable, are cell-destructive and so cannot evaluate cells and their interactions over time, or do not provide single-cell resolution. CellChorus® evaluates the performance and interactions of thousands of individual cells by applying Time- lapse Imaging Microscopy in Nanowell Grids (TIMING™) with neural network-based artificial intelligence (AI) to identify, track, and characterize behaviors and interactions of disease cells together with T-cells and other effector cells. The platform has been validated technically and commercially in an academic setting and an early access laboratory, but this model does not scale. We will develop and rigorously validate a Chronos™ instrument that delivers dynamic single-cell analysis based on the TIMING platform and applying our existing AI software and algorithms. The Chronos instrument will allow scientists, researchers, and manufacturing experts to apply dynamic single-cell analysis to catalyze development and manufacture of novel therapies in infectious diseases, oncology, and other medical sciences.
7. 项目总结/文摘

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Laurence J.N. Cooper其他文献

Incidence and Outcome of Early Hospital Readmission Following Hematopoetic Stem Cell Transplantation in Pediatric and Young Adult Patients
  • DOI:
    10.1016/j.bbmt.2014.11.391
  • 发表时间:
    2015-02-01
  • 期刊:
  • 影响因子:
  • 作者:
    Ossama Maher;Jorge Galvez Silva;Chloe Tillman;Demetrios Petropoulos;Laurence J.N. Cooper;Dean Lee;Laura L. Worth;Richard E. Champlin;Nidale Tarek;Priti Tewari
  • 通讯作者:
    Priti Tewari
Evaluating the Effector Function of Individual CD19-Specific T Cells to Assess the Therapeutic Impact of a Manufactured Product
  • DOI:
    10.1016/j.bbmt.2013.12.207
  • 发表时间:
    2014-02-01
  • 期刊:
  • 影响因子:
  • 作者:
    Harjeet Singh;Ivan Liadi;Gabrielle Romain;Navin Varadarajan;Laurence J.N. Cooper
  • 通讯作者:
    Laurence J.N. Cooper
Dual-Specificity CAR+ T Cells to Target B-Cell Malignancies and Opportunistic Fungal Infection
  • DOI:
    10.1016/j.bbmt.2013.12.202
  • 发表时间:
    2014-02-01
  • 期刊:
  • 影响因子:
  • 作者:
    Pappanaicken R. Kumaresan;Pallavi R. Manuri;Nathaniel D. Albert;Harjeet Singh;Brain Rabinovich;Janani Krishnamurthy;Sourindra N. Maiti;Olivares Simon;Tiejuan Mi;Dean Lee;Dimitrios Kontoyiannis;Helen Huls;Laurence J.N. Cooper
  • 通讯作者:
    Laurence J.N. Cooper
Automated Production of Clinical-Grade CMV-Specific T Cells to Implement Immunotherapy at the Bedside
  • DOI:
    10.1016/j.bbmt.2013.12.209
  • 发表时间:
    2014-02-01
  • 期刊:
  • 影响因子:
  • 作者:
    Priti Tewari;Pappanaicken R. Kumaresan;Matthew Figliola;Helen Huls;Kevin Longin;Katharina Ruhnke;Richard E. Champlin;Laurence J.N. Cooper
  • 通讯作者:
    Laurence J.N. Cooper
Reconstitution of Lymphocyte Subsets and Outcomes After Matched and Mismatched Hematopoietic Stem-Cell Transplantation
  • DOI:
    10.1016/j.bbmt.2012.11.409
  • 发表时间:
    2013-02-01
  • 期刊:
  • 影响因子:
  • 作者:
    Antonio di Stasi;Michelle Poon;Amir Hamdi;Hila Shaim;Susan Xie;Denai Milton;Roland Bassett;Gabriela Rondon;Elizabeth J. Shpall;Laurence J.N. Cooper;Dean A. Lee;Katayoun Rezvani;Richard E. Champlin;Stefan O. Ciurea
  • 通讯作者:
    Stefan O. Ciurea

Laurence J.N. Cooper的其他文献

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{{ truncateString('Laurence J.N. Cooper', 18)}}的其他基金

Phase 1 Study of Umbilical Cord Blood-Derived T Cells in Malignant B Cells
恶性 B 细胞中脐带血衍生 T 细胞的 1 期研究
  • 批准号:
    8732611
  • 财政年份:
    2013
  • 资助金额:
    $ 32.43万
  • 项目类别:
Phase 1 Study of Umbilical Cord Blood-Derived T Cells in Malignant B Cells
恶性 B 细胞中脐带血衍生 T 细胞的 1 期研究
  • 批准号:
    8417456
  • 财政年份:
    2013
  • 资助金额:
    $ 32.43万
  • 项目类别:
Quantitative single-cell biomarkers of T-cells to optimize tumor immunotherapy
T 细胞的定量单细胞生物标志物可优化肿瘤免疫治疗
  • 批准号:
    8413987
  • 财政年份:
    2012
  • 资助金额:
    $ 32.43万
  • 项目类别:
IMAGING T CELLS BY POSITRON EMISSION TOMOGRAPHY
通过正电子发射断层扫描对 T 细胞进行成像
  • 批准号:
    8373689
  • 财政年份:
    2012
  • 资助金额:
    $ 32.43万
  • 项目类别:
Quantitative single-cell biomarkers of T-cells to optimize tumor immunotherapy
T 细胞的定量单细胞生物标志物可优化肿瘤免疫治疗
  • 批准号:
    8547802
  • 财政年份:
    2012
  • 资助金额:
    $ 32.43万
  • 项目类别:
IMAGING T CELLS BY POSITRON EMISSION TOMOGRAPHY
通过正电子发射断层扫描对 T 细胞进行成像
  • 批准号:
    8539750
  • 财政年份:
    2012
  • 资助金额:
    $ 32.43万
  • 项目类别:
IMAGING T CELLS BY POSITRON EMISSION TOMOGRAPHY
通过正电子发射断层扫描对 T 细胞进行成像
  • 批准号:
    8711377
  • 财政年份:
    2012
  • 资助金额:
    $ 32.43万
  • 项目类别:
T-cell Therapy for B-lineage Acute Lymphoblastic Leukemia
B 系急性淋巴细胞白血病的 T 细胞疗法
  • 批准号:
    8681381
  • 财政年份:
    2010
  • 资助金额:
    $ 32.43万
  • 项目类别:
T-cell Therapy for B-lineage Acute Lymphoblastic Leukemia
B 系急性淋巴细胞白血病的 T 细胞疗法
  • 批准号:
    8112556
  • 财政年份:
    2010
  • 资助金额:
    $ 32.43万
  • 项目类别:
nCounter Prep Station and the Digital Analyzer
nCounter Prep Station 和数字分析仪
  • 批准号:
    7793214
  • 财政年份:
    2010
  • 资助金额:
    $ 32.43万
  • 项目类别:

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