Modification of GTP-binding proteins by deamidating and glycosylating toxins (P17)

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GTP-binding proteins are switch proteins, which regulate diverse cell signaling pathways and thereby control fundamental cellular functions. Various bacterial protein toxins target these GTP-binding proteins by post-translational modification, including deamidation and glycosylation, which results in the activation or inactivation of specific downstream signaling cascades. The project aims on the characterization of the molecular mechanisms of these toxin enzymes, the identification of determinants for substrate recognition and specificity, and the characterization of the functional consequences in cellular and pathological context.