Modification of GTP-binding proteins by deamidating and glycosylating toxins (P17)

通过脱酰胺和糖基化毒素修饰 GTP 结合蛋白 (P17)

• 批准号: 39256234
• 金额: --
• 依托单位: Abteilung I
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2007
• 资助国家: 德国
• 起止时间: 2006-12-31 至 2017-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/39256234?language=en
• 关键词: Modification; GTP; binding; proteins; deamidating

GTP-binding proteins are switch proteins, which regulate diverse cell signaling pathways and thereby control fundamental cellular functions. Various bacterial protein toxins target these GTP-binding proteins by post-translational modification, including deamidation and glycosylation, which results in the activation or inactivation of specific downstream signaling cascades. The project aims on the characterization of the molecular mechanisms of these toxin enzymes, the identification of determinants for substrate recognition and specificity, and the characterization of the functional consequences in cellular and pathological context.

GTP结合蛋白是一种开关蛋白，它调节多种细胞信号通路，从而控制基本的细胞功能。各种细菌蛋白毒素通过翻译后修饰靶向这些GTP结合蛋白，包括脱酰胺和糖基化，这导致特定下游信号级联的激活或失活。该项目旨在表征这些毒素酶的分子机制，确定底物识别和特异性的决定因素，以及表征细胞和病理背景下的功能后果。