Immuno histochemical Studies on degenerated disc and retro discal tissue in the internal deraugement of the temporo mandibular joint.

我们通过磁共振成像和关节镜手术研究了患有内部紊乱的 TMD 患者。结果表明，闭锁病例的粘连与最大开口、粘连与疼痛之间存在密切关系。对尸检时获得的人类颞下颌关节标本进行免疫组织化学检查。在椎间盘前移的情况下，硫酸角蛋白和 6-硫酸软骨素高度集中在 TMJ 椎间盘的前部区域。这些结果表明细胞外基质的分布与人类颞下颌关节的病理变化之间存在关系。我们对人类颞下颌关节的手术标本进行了免疫组织化学检查。 CD44在人体滑膜中集中分布。我们发现滑膜中分布着许多透明质酸受体。 TGF-β 和生腱蛋白在受影响的人滑膜中强烈表达。这些发现表明，生腱蛋白可能是滑膜炎分级的有用标记。

We studied TMD patients with internal derangement by MR imaging and arthroscopic surgery. It is resulted that closed lock cases had close relationship between adhesion and maximum opening, and that between adhesion and pain.The human TMJ specimens obtained at autopsy were examined immunohistochemically. In cases with anterior disc displacement, keratin sulfate and chondroitin 6-sulfate were highly localized in the anterial area of TMJ discs. These findings suggested that there is relationship between the distribution of extracellular matrix and pathological changes of the human TMJ.We examined surgical specimens of human TMJ immunohistochemically. CD44 distributed intensively in human synovi al membrane. We found there were many distribution of hyaluronic recepter in the synovial membrane. TGF-beta and tenascin were expressed intensively in the affected human synovial menbarane These findings suggested that tenascin might be an useful marker for grade of synovitis.