Immuno histochemical Studies on degenerated disc and retro discal tissue in the internal deraugement of the temporo mandibular joint.

颞下颌关节内部损伤中退变椎间盘和椎间盘后组织的免疫组织化学研究。

• 批准号: 05454540
• 负责人: IIZUKA Tadahiko
• 金额: $ 4.1万
• 依托单位: KYOTO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05454540/
• 关键词: Internal derangement; Keratin sulfate; Hyaluronic acid; Chondoritin 6-sulfate; Tenascin; CD44; MR imaging; 顎関節円板; 細胞外基質; コンドロイチン6硫酸; コンドロイチン4硫酸; 滑膜; 外側翼突筋; 免疫組織化学

We studied TMD patients with internal derangement by MR imaging and arthroscopic surgery. It is resulted that closed lock cases had close relationship between adhesion and maximum opening, and that between adhesion and pain.The human TMJ specimens obtained at autopsy were examined immunohistochemically. In cases with anterior disc displacement, keratin sulfate and chondroitin 6-sulfate were highly localized in the anterial area of TMJ discs. These findings suggested that there is relationship between the distribution of extracellular matrix and pathological changes of the human TMJ.We examined surgical specimens of human TMJ immunohistochemically. CD44 distributed intensively in human synovi al membrane. We found there were many distribution of hyaluronic recepter in the synovial membrane. TGF-beta and tenascin were expressed intensively in the affected human synovial menbarane These findings suggested that tenascin might be an useful marker for grade of synovitis.

我们研究了颞下颌关节紊乱病患者的磁共振成像和关节镜手术。结果表明，闭锁病例的粘连程度与最大开放度、粘连程度与疼痛程度密切相关。关节盘前移位者，关节盘前区硫酸角蛋白和6-硫酸软骨素高度集中。本研究对人颞下颌关节手术标本进行了组织化学研究，结果表明，细胞外基质的分布与颞下颌关节的病理变化有关。CD 44在人滑膜细胞膜上呈密集分布。我们发现透明质酸受体在滑膜中有多种分布。TGF-β和tenascin在滑膜中表达增强，提示tenascin可能是滑膜炎分级的一个有用的标志物。

项目成果

村上 賢一郎: "不正咬合と顎関節症、口腔外科の立場から顎関節症を考える" 日本MEAW研究会雑誌. 1. 151-163 (1994)

Kenichiro Murakami：“咬合不正和颞下颌关节紊乱，从口腔外科的角度考虑颞下颌关节紊乱”，日本 MEAW 研究小组杂志，1. 151-163 (1994)。

保坂栄勇,瀬上夏樹,村上賢一郎,飯塚忠彦: "顎関節鋭の診断精度に関する解別学的研究-屍体の上関節腔における病態像について-" 日本口腔外科学会雑誌. 39. 36-41 (1993)

Eiyu Hosaka，Natsuki Segami，Kenichiro Murakami，Tadahiko Iizuka：“颞下颌关节敏锐度诊断准确性的讨论研究-关于尸体上关节腔的病理图像-”日本口腔颌面外科杂志39。 36-41（1993）

吉田 博昭 他: "ヒト顎関節手術症例の円板におけるCD44の局在についての免疫組織化学的検討" 日口診誌. 8. 313-318 (1995)

Hiroaki Yoshida 等：“人类颞下颌关节手术病例椎间盘中 CD44 定位的免疫组织化学研究”Nichiguchi Kenshi。 8. 313-318 (1995)

岩代太他: "中頭蓋底の骨吸収を伴った顎関節滑膜性軟骨腫症の1例" 日口外誌. 40. 179-181 (1994)

Futoshi Iwashiro 等人：“颞下颌关节滑膜软骨瘤病伴中颅底骨吸收”，Nippon Oral Journal 40. 179-181 (1994)。

N.Segami,H.Hosaka,T.Iizuka,et al: "Arthroscopic abrasion arthroplasty in sheep TMJ." Journal of Oral and Maxillofacial Surgery. 51. 159-160 (1993)

N.Segami、H.Hosaka、T.Iizuka 等人：“羊颞下颌关节镜磨损关节置换术”。