Enantioselective Synthesis and Functionalization of Heptacyclo[6.6.0.02,6.03,13.04,11.05,9.010,14]tetradecane and Related Cage Compounds

沿着这一研究项目，人们提出了不同的方法来处理七环[6.6.0.02，6.03，13.04，11.05，9.010，14]tetradecane的高效合成和区域和对映体选择性(多)官能化。鉴于HCTD和金刚烷衍生的笼子之间的结构关系，特别是金刚烷，以及这些化合物在药物化学或材料科学等领域的许多应用；预计功能化的HTDC也可能成为药物修饰或机械力化学装置设计的有趣构件。如果成功，这项研究项目将打开一条快速进入这些结构的大门。最后，我们计划对它们的实用性进行初步测试。

Along this research project different approaches dealing with the efficient synthesis and the regio- and enantioselective (poly)fuctionalization of heptacyclo [6.6.0.02,6.03,13.04,11.05,9.010,14]tetradecane (HCTD) are proposed. Given the structural relationship between HCTD and adamantane derived cages, in particular diamantane, and the number of applications that these compounds have found in areas as diverse as medicinal chemistry or material science; it is envisaged that functionalized HTDC might also be interesting building blocks for the modification of drugs or the design of mechanochemical devices. In case of success, this research project will open an expeditious entry to these structures. Finally, we plan to preliminary test their practical utility.