Chiral cationic phosphonites: Applications towards the enantioselective synthesis of helicenes and related polyarenes

手性阳离子亚膦酸酯：在螺旋烯和相关聚芳烃的对映选择性合成中的应用

• 批准号: 209931430
• 负责人: Professor Dr. Manuel Alcarazo
• 金额: --
• 依托单位: Institut für Organische und Biomolekulare Chemie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2011
• 资助国家: 德国
• 起止时间: 2010-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/209931430?language=en
• 关键词: Chiral; cationic; phosphonites; Applications; towards

Along this research project a new approach for the enantioselective synthesis of helicenes and structurally related molecules is proposed, consisting on the assembling of these architectures through the hydroarylation of suitable alkynes using chiral Au-catalysts. Specifically, enantiopure cationic phosphonites will be used as ancillary ligands to prepare the necessary catalysts. It is of note that many racemic and diasteroselective syntheses are available for the preparation of the aforementioned structures, but enantioselective entries are really scarce; thus, in case of success, this research project might open an expeditious entry to these compounds, which are quite interesting in areas such as catalysis, molecular machines and/or liquid crystal technology.

沿着该研究项目提出了一种对映选择性合成螺旋烯和结构相关分子的新方法，该方法包括通过使用手性Au催化剂使合适的炔加氢芳基化来组装这些结构。具体地，对映体纯的阳离子亚膦酸酯将用作辅助配体以制备必要的催化剂。值得注意的是，许多外消旋和非对映选择性合成可用于制备上述结构，但对映选择性条目确实很少;因此，如果成功，该研究项目可能会迅速进入这些化合物，这些化合物在催化，分子机器和/或液晶技术等领域非常有趣。

项目成果

Synthesis of Cycloheptatrienes, Oxepines, Thiepines, and Silepines: A Comparison between Brønsted Acid and Au‐Catalysis

环庚三烯、Oxepines、Thiepines 和 Silepines 的合成：布伦斯台德酸和 Auâ 催化的比较

• DOI: 10.1002/ejoc.202001072
• 发表时间: 2020
• 期刊: European Journal of Organic Chemistry
• 影响因子: 2.8
• 作者: K. Sprenger;C. Golz;M. Alcarazo
• 通讯作者: M. Alcarazo