Locomotion-dependent neural processing within the thalamo-cortico-thalamic circuits (B19*)

丘脑-皮质-丘脑回路内运动依赖性神经处理 (B19*)

• 批准号: 394366011
• 金额: --
• 依托单位: Lehrstuhl für Neurobiologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/394366011?language=en
• 关键词: Locomotion; dependent; neural; processing; within

Physical activity, such as locomotion, can profoundly shape neural processing throughout the early visual system. Here, we ask how such activity-dependent modulation depends on glutamatergic signaling within thalamo-cortico-thalamic circuits. We will test this question using electrophysiology and optogenetics in awake, headfixed mice, disentangling the impact of feedforward and feedback circuits. Additionally, we will test the role of HCN channels, a key cellular determinant of thalamic activity, in controlling the firing mode during transitions in behavioral state.

身体活动，如运动，可以深刻地塑造整个早期视觉系统的神经处理。在这里，我们问这种活动依赖性调制如何依赖于丘脑-皮质-丘脑回路内的突触能信号。我们将使用电生理学和光遗传学在清醒的头部固定小鼠中测试这个问题，解开前馈和反馈电路的影响。此外，我们将测试HCN通道的作用，丘脑活动的关键细胞决定因素，在控制行为状态转换过程中的放电模式。