Development ofthe safely sterilization agent for prevention of secondary prion infection through medical instruments

预防医疗器械继发朊病毒感染的安全灭菌剂的研制

• 批准号: 23658277
• 负责人: TSUTSUMI Yuji
• 金额: $ 2.5万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23658277/
• 关键词: プリオン病; マンガンペルオキシダーゼ; 感染性除去; 二次感染防除; 医療器具洗浄剤

It has been well-known that abnormal prion protein is highly resistant against standard sterilization or chemical cleaning, and that high temperature-pressure or strong chemical treatment are required to sterilize its infectivity, however, these severe treatments are not applicable to some precision medical instrument, such as endoscopes. In this study, we investigated a capability of the enzyme, manganese peroxidase, to degrade and sterilize prion infectivity and tried to develop a new safely sterilization agent for precision medical instruments.

众所周知，异常朊病毒蛋白对标准灭菌或化学清洗具有很强的抵抗力，需要高温高压或强化学处理才能消除其传染性，但这些严格的处理并不适用于一些精密医疗器械，如内窥镜。在本研究中，我们研究了锰过氧化物酶对朊病毒感染性的降解和灭菌能力，并试图开发一种新的安全的精密医疗器械灭菌剂。