Molecular mechanisms underlying the reprogramming process of the totipotent fertilized eggs in mammals

受精后，通过将胚胎程序建立为全能合子，来协调调节卵子发生程序的删除和重编程。然而，重编程过程的分子机制还没有很好地理解。了解蛋白质参与母体mRNA和蛋白质的降解，以及ZGA在母体到合子过渡期的发生，有助于阐明卵母细胞重塑为全能合子的分子机制，也可能对多能性的调节产生影响。

After fertilization, erasure of the oogenic program and reprogramming by establishing the embryonic programs into totipotent zygote are co-ordinately regulated. However, molecular mechanisms underlying the reprogramming process are not well understood. Understanding of the involvement of proteins in the degradation of maternal mRNA and proteins, and also the onset of ZGA at the maternal-to-zygotic transition helps elucidate molecular mechanisms governing the remodeling of the oocyte into the totipotent zygote and may also have implications for regulation of pluripotency.