Fever and producing cytokines after Zoledronic acid administration

服用唑来膦酸后发烧并产生细胞因子

• 批准号: 23659378
• 负责人: MOURI Hisatsugu
• 金额: $ 2.33万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23659378/
• 关键词: ゾレドロネート; 発熱; サイトカイン; 炎症性サイトカイン

The aim of this study was define the mechanism of fever after Zoledronic acid(Zol) administration.9 of 10 cases experienced fever.All the serum samples obtained before and after Zol administration were used cytokine analysis.Supernatant samples of mononuclear cells after stimulation by Zol were selected (three over 38 degrees, two 37.9 - 37.0 degrees, and one 36.9 degrees or less). Cytokine levels of the case with apyrexia were almost no change after Zol administration. IP-10, MCP-1, and GRO were elevated in other cases.The clear difference between low grade fever cases and a high fever cases was not seen. Results of analysis in supernatant was also the same. More cases without fever were required. The predictive factor of fever after Zol administration was not clarified.

为探讨唑来膦酸（Zol）致发热的机制，10例患者中有9例出现发热，分别于用药前后采集血清标本，进行细胞因子分析，其中3例为38度以上，2例为37.9 ~ 37.0度，1例为36.9度以下。发热患者服用Zol后细胞因子水平几乎无变化。其他病例IP-10、MCP-1和GRO均升高，低热与高热之间无明显差异。上清液的分析结果也相同。需要更多无发热病例。Zol给药后发热的预测因素尚未阐明。