Fever and producing cytokines after Zoledronic acid administration

为明确佐来膦酸(Zol)治疗后发热的发生机制，10例患者中有9例出现发热，用药前后采集血清标本进行细胞因子分析，取刺激后单个核细胞培养上清标本(3例38度以上，2例37.9-37.0度，1例36.9度以下)。应用Zol后，无热证患者细胞因子水平基本无变化。其他病例IP-10、MCP-1、GRO均升高，低热与高热之间无明显差异。上清液的分析结果也是相同的。需要更多没有发烧的病例。Zol用药后发热的预测因素尚不清楚。

The aim of this study was define the mechanism of fever after Zoledronic acid(Zol) administration.9 of 10 cases experienced fever.All the serum samples obtained before and after Zol administration were used cytokine analysis.Supernatant samples of mononuclear cells after stimulation by Zol were selected (three over 38 degrees, two 37.9 - 37.0 degrees, and one 36.9 degrees or less). Cytokine levels of the case with apyrexia were almost no change after Zol administration. IP-10, MCP-1, and GRO were elevated in other cases.The clear difference between low grade fever cases and a high fever cases was not seen. Results of analysis in supernatant was also the same. More cases without fever were required. The predictive factor of fever after Zol administration was not clarified.