In vivo analysis of EMT by a newly designed optic probes with dual secretory

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We developed a mouse model for in vivo optic imaging by implanting subcutaneously tumor cells. Tumor cells express constitutively optic probes (secretory C-Luc probe and conventional F-Luc probe). We monitored tumor cell growth, and signals from optic probes (F-Luc) by imaging and by blood (C-Luc). We could image tumors by optic imaging parallel to tumor size and also monitor tumor expansion non-invasively by an aliquot of blood (1-2ul).In the present study, we could check tumor expression/depression by the newly developed optic probes by in vivo imaging and by measuring blood samples. These probes will contribute to a future diagnosis/therapy as a new monitoring tool or to develop a new drug.