Involvement of claudin-network in the development of ARDS caused by influenza virus infection

我们探讨了claudins可能参与急性肺损伤的发展。在实时PCR分析中，cluadin 2和4的表达在损伤的肺中增加，而claudin 5、6、9和18-1的表达减少。在免疫组化分析中，在损伤肺的支气管上皮细胞中检测到claudin 2和4的表达。在claudin 4基因破坏的小鼠中，LPS给药引起的肺水肿倾向于恶化。这些结果提示claudins可能参与了ARDS的发生发展。

We addressed the possible involvement of claudins in the development of acute lung injury. In a real-time PCR analysis, expression of cluadin 2 and 4 was increased in the injured lungs, whereas that of claudin 5, 6, 9 and 18-1 was reduced. In an immunohistochemical analysis, expression of claudin 2 and 4 was detected in the bronchoepithelial cells of injured lungs. Lung edema caused by LPS administration tended to be worsened in claudin4 gene-disrupted mice. These results suggest that claudins may be involved in thedevelopment of ARDS.