Analysis on the present state in multi-drug resistant Mycobacterium tuberculosis infection and its clinical background in China

我们与中山大学附属第三医院和广州市胸科医院合作，调查了广州市耐多药结核病（TB）的现状。在胸科医院，耐多药结核病和广泛耐药结核病的比例为16。7%，2. 0%，2008年9。1%和0。9%，2009年为13。5%和0. 2010年的报告率分别为3%，这表明在研究期间，尽管耐多药结核病没有变化，但广泛耐药结核病有下降的趋势。对50株MDR-TB和5株XDR-TB的耐药基因rpoB、kat G、inhA和ahpC进行了测序，突变率分别为90%、63%、22%和6%。此外，我们通过测量BMI、血清白蛋白水平、WBC计数、T细胞和NK细胞比例、CD 4/CD 8比值以及外周血淋巴细胞对结核抗原的反应性来分析这些患者的宿主因素，我们没有发现药物敏感和MDR-TB之间的任何显著差异。

We investigated the present state in multi-drug resistant tuberculosis (TB)in Guangzhou City, Guangdong Province, China by collaborating with the Third Affiliated Hospital of Sun Yat-Sen University and Guangzhou Chest Hospital. In the Chest Hospital, the proportion of MDR-TB and extensively drug-resistant (XDR)-TB was 16. 7%and 2. 0%in 2008, 9. 1%and 0. 9%in 2009 and 13. 5%and 0. 3%in 2010, respectively, which showed that XDR-TB tended to be decreased during the study period though no change in MDR-TB. We sequenced the drug resistance genes, rpoB, kat G, inhA and ahpC, in 50 strains of MDR-TB and 5 strains of XDR-TB, and mutation was detected at 90%, 63%, 22%and 6%, respectively. In addition, we analyzed the host factors in these patients by measuring BMI, serum albumin levels, WBC counts, proportion of T and NK cells, CD4/CD8 ratio and reactivity of peripheral blood lymphocytes to TB antigens, and we did not find any significant difference between drug-sensitive and MDR-TB.