Precision macromolecules for the sequence-controlled presentation of supramolecular ligands (A11+)
Precision macromolecules for the sequence-controlled presentation of supramolecular ligands (A11+)
用于超分子配体序列控制呈现的精密大分子 (A11)
批准号：
394582032
负责人：
金额：
$0.0万
依托单位国家：
德国
项目类别：
Collaborative Research Centres
财政年份：
2018
资助国家：
德国
项目状态：
已结题
起止时间：
2017-12-31 至 2021-12-31
中文摘要
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英文摘要
We will apply sequence-controlled oligo(amidoamines) as a new platform for the multivalent presentation of non-natural supramolecular binding motifs (A1, A2, A3) in combination with biological ligands and sensor molecules (A10). The resulting macromolecular ligands will be analyzed for their modulation of different proteins such as the N-D1 interface of p97 (B2), 14-3-3 protein (B4), Survivin and Taspase1 (B5), mitotic regulators (B6) and Ndc80-microtubule interactions (B7).
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