Precision macromolecules for the sequence-controlled presentation of supramolecular ligands (A11+)

我们将应用序列控制寡聚(氨胺)作为一种新的平台，与生物配体和传感器分子(A10)相结合，实现非天然超分子结合基序(A1、A2、A3)的多价呈现。将分析得到的大分子配体对不同蛋白质的调节作用，如p97的N-D1界面(B2)、14-3-3蛋白(B4)、Survivin和Taspase1(B5)、有丝分裂调节因子(B6)和Ndc80-微管相互作用(B7)。

We will apply sequence-controlled oligo(amidoamines) as a new platform for the multivalent presentation of non-natural supramolecular binding motifs (A1, A2, A3) in combination with biological ligands and sensor molecules (A10). The resulting macromolecular ligands will be analyzed for their modulation of different proteins such as the N-D1 interface of p97 (B2), 14-3-3 protein (B4), Survivin and Taspase1 (B5), mitotic regulators (B6) and Ndc80-microtubule interactions (B7).