Chiral synthetic macromolecules - control of sequence and stereochemistry

手性合成大分子 - 序列和立体化学的控制

• 批准号: DP210101904
• 负责人: A/Prof Jiangtao Xu
• 金额: $ 26.74万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-07-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210101904
• 关键词: Chiral; synthetic; macromolecules; control; sequence

This project aims to assemble a library of novel chiral polymers mimicking natural peptides with precisely controlled primary structures using emerging synthetic technologies. A systematic investigation of these synthetic materials will provide an in-depth understanding of how sequence and stereochemistry influence chemical and physical properties. Employing rational design principles, desired functionality could be optimised through the selective modification of polymer structure. These materials should be able to emulate the unique properties and functionality of natural peptides/proteins, making them invaluable for biochemical applications, such as molecular recognition and asymmetric catalysis.

该项目旨在利用新兴的合成技术组装一个新型手性聚合物库，模拟具有精确控制的一级结构的天然肽。对这些合成材料的系统研究将深入了解序列和立体化学如何影响化学和物理性质。采用合理的设计原则，可以通过选择性地改变聚合物结构来优化所需的功能性。这些材料应该能够模仿天然肽/蛋白质的独特性质和功能，使它们在生物化学应用中具有宝贵的价值，例如分子识别和不对称催化。