Chiral synthetic macromolecules - control of sequence and stereochemistry

该项目旨在利用新兴的合成技术组装一个新型手性聚合物库，模拟具有精确控制一级结构的天然多肽。对这些合成材料的系统研究将提供对序列和立体化学如何影响化学和物理性质的深入了解。采用合理的设计原则，可以通过对聚合物结构的选择性修饰来优化所需的功能。这些材料应该能够模拟天然多肽/蛋白质的独特性质和功能，使它们在分子识别和不对称催化等生物化学应用中具有无价的价值。

This project aims to assemble a library of novel chiral polymers mimicking natural peptides with precisely controlled primary structures using emerging synthetic technologies. A systematic investigation of these synthetic materials will provide an in-depth understanding of how sequence and stereochemistry influence chemical and physical properties. Employing rational design principles, desired functionality could be optimised through the selective modification of polymer structure. These materials should be able to emulate the unique properties and functionality of natural peptides/proteins, making them invaluable for biochemical applications, such as molecular recognition and asymmetric catalysis.