The effect of reciprocal fixation to keep muscle strength secondary to joint immobilization

相互固定对保持关节固定后肌肉力量的作用

• 批准号: 24650327
• 负责人: OKI Sadaaki
• 金额: $ 0.42万
• 依托单位: Prefectural University of Hiroshima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24650327/
• 关键词: リハビリテーション医学; 廃用性筋萎縮; 骨格筋; 萎縮; 張力; ラット

To investigate the effect of reciprocal fixation to keep muscle strength secondary to joint immobilization, an experimental study was carried out. Twenty-four female Wistar rats were used in this study. The rats were divided into four groups (extension fixation group, flexion fixation group, reciprocal fixation group, and control group), each group containing 6 rats. For the extension fixation group, unilateral ankle cast fixations were carried out in extension position. For the flexion fixation group, unilateral ankle cast fixations were carried out in full flexion position. For the reciprocal fixation group, unilateral ankle cast fixations were carried out in full extension position (8 hours a day) and full flexion position (16 hours a day) reciprocally. For the control group, joint fixations were not carried out. After 4 days, isometric twitch tension, maximum tetanic tension, relative weight ratio, and histological change of soleus and tibialis anterior muscles were examined. Muscle atrophy was prevented in the reciprocal fixation group. The maximum tetanic tension of tibialis anterior muscles in the reciprocal fixation group was not enough to the control group. Further maneuver in addition to the reciprocal fixation is needed to keep muscle strength.

为探讨关节制动后的相互固定对肌肉力量的影响，进行了实验研究。本研究中使用了24只雌性Wistar大鼠。将大鼠分为4组（伸展固定组、屈曲固定组、交互固定组和对照组），每组6只。伸位固定组采用伸位单侧踝关节石膏固定。屈曲固定组在完全屈曲位进行单侧踝关节石膏固定。相互固定组分别于完全伸展位（每天8小时）和完全屈曲位（每天16小时）进行单侧踝关节石膏固定。对于对照组，不进行关节固定。4 d后，检测比目鱼肌和胫骨前肌的等长收缩张力、最大强直张力、相对重量比及组织学变化。相互固定组的肌肉萎缩得到了预防。交互固定组胫前肌最大强直张力低于对照组。除了相互固定之外，还需要进一步的动作来保持肌肉力量。

项目成果

廃用性筋萎縮に対する筋伸張位短縮位交互固定法による筋力の維持-ラットによる実験的研究-

通过交替肌肉伸展和缩短来维持肌肉力量以治疗废用性肌肉萎缩 - 使用大鼠的实验研究 -

• 期刊: 総合リハビリテーション
• 作者: 沖貞明;積山和加子;梅井凡子;小野武也;大塚彰
• 通讯作者: 大塚彰