Sarcopenia:Biomarker and Prevention.

肌肉减少症，即与年龄相关的骨骼肌质量损失，在老年人中非常普遍。本研究的第一个目的是评价社区居住的日本老年人中肌肉减少症的生物标志物（研究1）。第二个目的是调查阻力训练与多种营养素补充剂相结合对肌肉质量和低肌肉质量的虚弱老年人的身体表现的影响（研究2）。健康老年人（321）参加了研究1。研究2将77名受试者分为运动补充组（S/Ex：n = 38）和运动组（Ex：n = 39），并随访3个月。研究1提示血清IGF-1和握力是肌少症的生物标志物。研究2表明，阻力训练和多营养补充剂的组合可能比仅基于阻力训练的干预更有效地改善肌肉减少症。

Sarcopenia, the age-related loss of skeletal muscle mass, is highly prevalent in older adults. The first aim of this study was to evaluate the biomarker of sarcopenia in community-dwelling Japanese older adults (Study 1). The second aim was to investigate the effects of the combination of resistance training with a multinutrient supplementation on muscle mass and physical performance in frail older adults with low muscle mass (Study 2).Healthy older adults (321) participated in the study 1. In the study 2, a total of 77 participants were divided into the exercise group with supplementation (S/Ex: n = 38) and exercise group (Ex: n = 39), and followed for 3 months.The study 1 was suggested that the serum IGF-1 and grip strength are the biomarker for the sarcopenia. The study 2 suggest that the combination of resistance training and multinutritional supplementation may be more effective at improving sarcopenia than an intervention only based on resistance training.