The initial diagnosis for lung cancer using isotope ratio

使用同位素比值初步诊断肺癌

• 批准号: 24650635
• 负责人: KAWASHIMA Hiroto
• 金额: $ 2.41万
• 依托单位: Akita Prefectural University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24650635/
• 关键词: 肺がん; 初期診断; 安定同位体比; 分析化学; 腫瘍診断学; 呼気診断; 揮発性有機化合物; 加熱濃縮器; 加熱濃縮

For the development of the inspection method for lung cancer, we conducted various tests. As the results, the developed method can be measured lot of VOCs for high accuracy, and reduced a patient burden by small exhalation. As the exhalation test, there is almost no difference exhalation by different food and no long time by prohibited food and drinks before exhalation test. The exhalation for smokers included benzene than non-smoker. The benzene of exhalation was decreasing after smoking 6 hours. And, the exhalation for smoking menthol cigarettes included high level benzene and toluene. Using thermal desorption system, carbon isotope for many VOCs can be measured for high precision and accuracy.

为了开发肺癌的检查方法，我们进行了各种测试。结果，所开发的方法可以高精度地测量大量VOC，并且通过少量呼气减轻了患者负担。在呼气试验中，不同食物对呼气的影响几乎没有差异，呼气试验前也没有长时间的禁食和禁饮。吸烟者呼出气含苯量高于非吸烟者。吸烟6h后呼出苯减少。而且，吸薄荷香烟的呼出物包括高水平的苯和甲苯。利用热脱附系统，可以测量许多挥发性有机化合物的碳同位素，具有高精度和准确度。

项目成果

川島・発生源解析チームのHP

川岛源分析团队 HP

Hydrogen isotope analysis of benzene and toluene emitted from vehicles

• DOI: 10.1016/j.atmosenv.2013.02.029
• 发表时间: 2013-06
• 期刊: Atmospheric Environment
• 影响因子: 5
• 作者: Namiko Kikuchi;H. Kawashima

Stable hydrogen isotope ratios and fractionation factors of VOCs during ultraviolet irradiation

紫外线照射下VOCs的稳定氢同位素比和分馏因子

• 发表时间: 2013
• 作者: Nami Kikuchi;Hiroto Kawashima
• 通讯作者: Hiroto Kawashima

Measurement of the stable carbon isotope ratio of atmospheric volatile organic compounds using chromatography, combustion, and isotope ratio mass spectrometry coupled with thermal desorption

• DOI: 10.1016/j.atmosenv.2014.02.033
• 发表时间: 2014-06
• 期刊: Atmospheric Environment
• 影响因子: 5
• 作者: H. Kawashima;Mai Murakami

光化学反応によるベンゼン,トルエンの水素安定同位体の同位体効果

光化学反应导致苯和甲苯中稳定氢同位素的同位素效应

• 发表时间: 2012
• 作者: 松本純明;伊東潤二;塩尻好恵;Ellis Reinherz,戸井雅和;吉川清次;菊池奈美,川島洋人
• 通讯作者: 菊池奈美,川島洋人