Analysis of molecular mechanisms underlying lymphocyte homing using high endothelial venule-specific conditional knockout mice

点击翻译按钮获取中文摘要

Circulating lymphocytes migrate into the parenchyma of lymph nodes through specialized blood vessels called high endothelial venules(HEVs). In this process, chemokines are important for the activation of lymphocyte integrins and the subsequent firm attachment of lymphocytes to HEVs. By generating novel HEV-specific conditional knockout mice, we demonstrate in this study that heparan sulfate sequesters chemokines on the surface of HEVs and presents them to lymphocytes to facilitate this migratory process.