3D nano-lattices substrate for human pluripotent stem cells culture

人多能干细胞（human pluripotent stem cells，hPSC）是组织工程、药物筛选和再生医学的重要资源。细胞微环境因子在调节hPSC功能中起着关键作用，但用合成组分控制它们具有挑战性。在这个项目中，我们专注于开发一种基于微工程工具和技术的3D纳米网格支架，用于维持多能干细胞培养。三维纳米晶格支架上的hPSC显示出生长速率，并且它们保留了其多能性。

Human pluripotent stem cells (hPSCs) are useful resources fortissue engineering, drug screening, and regenerative medicine. Cellular microenvironmental cues play critical roles in regulating hPSCs functions, but it is challenging to control them with synthetic components. In this project, we focus to develop a 3D nano-lattices scaffold for maintaining pluripotent stem cell culture based on micro-engineering tools and techniques. hPSCs on 3D nano-lattics scaffold showed a growth rate and they retained their pluripotency.