To develop neural chips using hPSC-derived neurons for facilitating in-vitro investigations of neural networks by nanofibers

我们利用胚胎或诱导多能干细胞构建了精心设计的神经网络。地形和生物化学的细胞生长线索都被图案化，以指导衍生轴突和树突的生长和合成。此外，排列纳米纤维的地形和微流控电路以及集成的微电极阵列被用于更主动的控制和监测蜂窝网络活动。如果成功，该神经元芯片可作为药物筛选的模型系统。

We construct well-designed neural networks by using either embryonic or induced pluripotent stem cells. Both topographic and biochemical cell growth cues are patterned to guide the growth and connation of derived axons and dendrites. In addition, aligned nanofibers-based topographic and microfluidic circuits as well as integrated microelectrode arrays are used for more active control and monitoring cellular network activities. If successful, the derived neuron chips can be useful as model system for advanced study of drug screening.