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Comprehensive studies of genes responsible for biosynthesis of fusicoplagin diterpenoids in liverworts, and their use to development of reconstituted biosynthesis system

Comprehensive studies of genes responsible for biosynthesis of fusicoplagin diterpenoids in liverworts, and their use to development of reconstituted biosynthesis system
地钱中负责 Fusicoplagin 二萜生物合成的基因的综合研究及其在重建生物合成系统开发中的应用
批准号:
24651247
负责人:
KENMOKU Hiromichi
金额:
$2.5万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-04-01 至 2014-03-31

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中文摘要
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英文摘要
Novel fusicoplagins, isolated from the leafy liverwort Plagiochila sciophila, are diterpenoids thay are potent inducers of differentiation in human myelocytic leukemia HL-60 cells. Because the fusicoplagins are a minuscule amount in the liverwort, construction of the stable supply method is a matter of great urgency. Therefore, studies aiming at the elucidation of the entire biosynthetic genes was carried out using a comprehensive transcriptome method. The predicted biosynthetic genes were discovered and the function of the diterpene cyclases was analyzed using heterologous gene expression system.
期刊论文(26)
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会议论文
Seed Dormancy Breaking Diterpenoids from the Liverwort Plagiochila sciophila and their Differentiation Inducing Activity in Human Acute Promyelocytic Leukemia HL-60 Cells
打破地草种子休眠的二萜类化合物及其在人急性早幼粒细胞白血病 HL-60 细胞中的分化诱导活性
DOI: --
发表时间: 2014
期刊: Natural Product Communications
影响因子: 1.8
作者: [Kenmoku, H., Tada, H., Oogushi, M., Esumi, T., Takahashi, T., Noji, M., Sassa, T., Toyota, M., Asakawa, Y.]
通讯作者: Y.
Heterologously expressed β-hydroxyl fatty acids from a metagenomic library of a marine sponge
来自海绵宏基因组库的异源表达的β-羟基脂肪酸
DOI: 10.1016/j.bmcl.2012.10.082
发表时间: 2012
期刊: Bioorg. Med. Chem. Lett.
影响因子: --
作者: [R. He, T. Wakimoto, Y. Egami, H. Kenmoku, T. Ito, Y. Asakawa, I. Abe]
通讯作者: I. Abe
真菌類分生胞子形成誘導因子の生合成における酵素阻害剤の探索
寻找真菌分生孢子形成诱导因子生物合成中的酶抑制剂
DOI: --
发表时间: 2014
期刊:
影响因子: --
作者: [R. He, T. Wakimoto, Y. Egami, H. Kenmoku, T. Ito, Y. Asakawa, I. Abe, 兼目裕充,曽我達也,鴫原隆,木村榮一,佐々武史,高橋宏暢,野路征昭,豊田正夫,浅川義範, 兼目裕充,高橋宏暢,大久保翔,江角朋之,豊田正夫,浅川義範]
通讯作者: 兼目裕充,高橋宏暢,大久保翔,江角朋之,豊田正夫,浅川義範
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [R. He, T. Wakimoto, Y. Egami, H. Kenmoku, T. Ito, Y. Asakawa, I. Abe, 兼目裕充,曽我達也,鴫原隆,木村榮一,佐々武史,高橋宏暢,野路征昭,豊田正夫,浅川義範, 兼目裕充,高橋宏暢,大久保翔,江角朋之,豊田正夫,浅川義範, 兼目裕充,曽我達也,鴫原隆,木村榮一,佐々武史,高橋宏暢,野路征昭,豊田正夫,浅川義範, 兼目裕充,大櫛恵,竹上沙也加,佐々武史,豊田正夫,浅川義範, 曽我達也,兼目裕充,鴫原隆,木村榮一,佐々武史,高橋宏暢,野路征昭,豊田正夫,浅川義範]
通讯作者: 曽我達也,兼目裕充,鴫原隆,木村榮一,佐々武史,高橋宏暢,野路征昭,豊田正夫,浅川義範
17
    Fanctional analysis of diterpene synthase responsible for fungal conidiation Inducing and its diterpene reseptor discovery
    • 批准号:
      26350965
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.08万
    • 财政年份:
      2014
    • 负责人:
      KENMOKU Hiromichi
    • 依托单位:
    Studies of terpene cyclases responsible for the biosynthesis of oil components in Marchantia polymorpha and their use to metabolic engineering system.
    • 批准号:
      22710226
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $1.75万
    • 财政年份:
      2010
    • 负责人:
      KENMOKU Hiromichi
    • 依托单位:
    海外基金