The Influence of Gene and Environmental Interactions on Cognitive and Emotional Status in Older Adults

基因和环境相互作用对老年人认知和情绪状态的影响

• 批准号: 24653194
• 负责人: GONDO Yasuyuki
• 金额: $ 2.41万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24653194/
• 关键词: 環境; 遺伝; 認知機能; 感情; 高齢期

This study was designed to evaluate the influence of gene-environment interactions on the cognitive function or emotional state in older adults. Parallel studies for the development of measurement systems of environmental condition and gene typing were performed.Original methods to evaluate school achievement in childhood, job experience (complexity and stress) in midlife were developed. SNP typing for 6 candidate genes were also performed. A series of analyses to test the interaction of job complexity in midlife and each gene polymorphism on cognition were performed. Although the results showed a possibility of gene and environmental interaction in some genes (e.g., Klotho), the statistical power was too small to fully support this hypothesis. These results indicate that a more deliberate choice of control variables such as the medical condition is needed to clarify gene-environment interactions in a complex human life context.

本研究旨在评估基因-环境相互作用对老年人认知功能或情绪状态的影响。同时进行了环境条件和基因分型测量系统的开发研究，开发了评估儿童时期学校成绩和中年工作经历（复杂性和压力）的原始方法。对6个候选基因进行SNP分型。通过一系列的分析来检验中年工作复杂性和各基因多态性对认知的交互作用。虽然结果表明在某些基因中存在基因和环境相互作用的可能性（例如，Klotho），统计功效太小，无法完全支持这一假设。这些结果表明，在复杂的人类生活背景下，需要更慎重地选择控制变量，如医疗条件，以澄清基因与环境的相互作用。

项目成果

パーソナリティと長寿に関する研究動向

人格与长寿的研究趋势

• 发表时间: 2013
• 期刊: 老年社会科学
• 作者: Benigni A;Orisio S;Noris M;Iatropoulos P;Castaldi D;Kamide K;Rakugi H;Arai Y;Todeschini M;Ogliari G;Imai E;Gondo Y;Hirose N;Mari D;Remuzzi G;権藤恭之
• 通讯作者: 権藤恭之

Genetic variants at the 9p21 locus contribute to atherosclerosis through modulation of ANRIL and CDKN2A/B

• DOI: 10.1016/j.atherosclerosis.2011.11.017
• 发表时间: 2012-02-01
• 期刊: ATHEROSCLEROSIS
• 影响因子: 5.3
• 作者: Congrains, Ada;Kamide, Kei;Rakugi, Hiromi
• 通讯作者: Rakugi, Hiromi

Sources of variation on the mini-mental state examination in a population-based sample of centenarians.

• DOI: 10.1111/jgs.12370
• 发表时间: 2013-08
• 期刊: Journal of the American Geriatrics Society
• 影响因子: 6.3
• 作者: Dai T;Davey A;Woodard JL;Miller LS;Gondo Y;Kim SH;Poon LW
• 通讯作者: Poon LW

メモの利用が高齢者の展望的記憶に及ぼす補償効果の検証と効果的なメモの検討

验证备忘录使用对老年人前瞻记忆的补偿作用并检验有效备忘录

• 发表时间: 2013
• 期刊: 応用老年学
• 作者: Davey;A.;Dai;T.;Woodard;J. L.;Miller;L. S.;Gondo;Y.;Johnson;M. A.;Poon;L. W;山根裕樹,権藤恭之,蓮花のぞみ,石岡良子
• 通讯作者: 山根裕樹,権藤恭之,蓮花のぞみ,石岡良子

Does Type of Activities Matter? Age and Gender Differences in Leisure Activities Among Japanese Older Adults

活动类型重要吗？

• 发表时间: 2013
• 作者: Ogawa M;Ishioka Y;Gondo Y;Kozono M;Masui Y;Nakagawa T;Tabuchi M ;Tatsuhira Y;Ikebe K;Kamide K;Arai Y;Ishizaki T;& Takahashi R
• 通讯作者: & Takahashi R