Development of effective nano-sizing method for dispersible additive-free poorly-water-soluble drugs and its application

本研究旨在通过无添加剂纳米施胶技术解决难溶性药物的大部分问题（加速溶出、减少添加剂、抑制团聚和改善固体分散）。以可食用的二氧化碳为溶剂，以摩擦电荷为分散力，实现了对难溶性药物的无添加纳米施胶（粒径小于100 nm）。结果，解决了上述问题，此外，发现了纳米尺寸药物的过饱和溶出度（超过饱和浓度的10%）。

This study aimed to solve most of problems of poorly-water-soluble drugs (acceleration of dissolution, reduction of additives, suppression of aggregation and improvement of solid dispersion) by additive-free nano-sizing. By using esculent carbon dioxide as the solvent and applying triboelectric charge as the dispersion force, additive-free nano-sizing (less than 100nm diameter) of poorly-water soluble drugs was achieved. As the result, above mentioned problems have been solved, in addition, supersaturated dissolution (10% excess dissolution to the saturated concentration) of the nano-sized drugs has been found.