Study on the mechanism of tissue disruption induced by decreased expression of cell-cell adhesion proteins

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Intracranial pressure changes during head impact cause brain injuries such as vasogenic edema and cerebral contusion.Human umbilical vein endothelial cells were subjected to positive and negative pressure, and the transendothelial electrical resistance (TEER) was measured between 15 min and 24 h after pressure loading for quantifying the formation of an integral monolayer of endothelial cells.TEER decreased considerably at 15 min and 6 h post-loading, with these changes being significant in positive pressure with larger amplitude and shorter duration and in all types of negative pressures compared to pre-loading.The changes in intracranial pressure during head impact impair endothelial barrier function by the disruption of the integrity of endothelial cell-cell junctions, and the degree of increase in endothelial permeability depends on the amplitude, duration, and direction (compressive and tensile) of the impulsive pressure.