Synthesis of high-strength tissue invasive bone substitute materials by unidirectional freezing and development of control method of their porous structure

单向冷冻合成高强度组织侵入性骨替代材料及其多孔结构控制方法开发

• 批准号: 24656468
• 负责人: TAMON Hajime
• 金额: $ 2.58万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24656468/
• 关键词: 骨補填材; 連通多孔構造; 一方向凍結; 焼成; ヒドロキシアパタイト; リン酸三カルシウム; リン酸カルシウム系セラミ

Organic slurry containing hydroxyapatite (HAP) particles or tricalcium phosphate (TCP) particles was prepared. Then HAP or TCP monolith was synthesized by unidirectional freezing of the organic slurry, freeze-drying, and calcination in air. In the case where resorcinol-formaldehyde (RF) gel was used as organic slurry, the pore size and compressive strength of monolith are 0.1mm and 2.3MPa. However, the compressive strength was not enough for a practical use.When t-butanol and polyvinylpyrrolidone were used as solvent and binder, it was possible to produce HAP or TCP monolith having pore size of more than 0.1mm and a compressive strength of more than 10MPa. In addition, a method controlling the porous structure of the monolith was proposed with the help of unidirectional freezing simulation.

制备了含有羟基磷灰石（HAP）颗粒或磷酸三钙（TCP）颗粒的有机浆料。然后将有机浆料单向冷冻、冷冻干燥、空气煅烧合成HAP或TCP整体体。间苯二酚-甲醛（RF）凝胶作为有机浆料时，整体体孔径为0.1mm，抗压强度为2.3MPa。然而，抗压强度不足以实际应用。以丁醇和聚乙烯吡咯烷酮为溶剂和粘结剂，可制得孔径大于0.1mm、抗压强度大于10MPa的HAP或TCP整体体。在此基础上，提出了一种基于单向冻结模拟的单块体多孔结构控制方法。