Neural mechanism of ultrasonic vocalization of mice

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Ultrasonic vocalization (USV) of mice is composed of a sequence of vocal elements. Therefore, neural mechanism of ultrasonic vocalization has intensely been focused. In this study, we investigated changes in USVs of DBA2/J mice according to hearing loss. As a result, the average fundamental frequency of vocal elements was decreased in 6 ~ 8 weeks of mice as developmental effect, while it was increased in 11 ~ 13 weeks of mice according to hearing loss. We also executed in vitro experiments for 64-ch multi-site recording from acute brain slices including auditory cortex of SAM mice. Using current source density analysis, we visualized spatiotemporal dynamics in the auditory cortex, which are initial activity propagations from deep to shallow layer, and additional propagations along horizontal direction.