The role of AID expression in the development of EBV associated gastric cancer

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We analyzed AID expression in EBV-associated Gastric cancers by immunohistochemistry, however,specific reaction by the antibody could not be detected in the paraffin-embedded tissue section. High-density DNA oligonucleotide arrays was performed in mononuclear cells of the patients with EBV-associated Gastric cancers. Copy number variation which specifically occured in the patients will be identified from big data. The association of DNA methylation in the development of EBV-associated Gastric cancers was also examined. We found several tumor suppressor genes whose promoter regions were specificcly methylated in EBV-associated Gastric cancers.Inactivation of these genes may suppress their function as tumor suppressor genes or tumor-associated antigen to develop and maintain EBVaGCs.